A Ni-catalyzed asymmetric C(sp)-P cross-coupling reaction for the synthesis of P-stereogenic alkynylphosphines.

Due to the high reactivity of the triple bond, P-stereogenic alkynylphosphines could be easily derivatized, serving as universal building blocks for structurally diverse phosphine compounds. However, the synthesis of alkynylphosphines via direct P-C bond formation was unprecedented. Here, we report an efficient method for the synthesis of P-stereogenic alkynylphosphines with high enantioselectivity via a Ni-catalyzed asymmetric cross-coupling reaction. The reaction could tolerate a variety of functional groups, affording products that can be converted into useful phosphine derivatives.

[Clinical application of sinus floor elevation guided by cone-beam computer tomography].

PURPOSE: To investigate the value of using con-beam computer tomography (CBCT) to evaluate bone volume in the edentulous area of posterior maxilla, and guide sinus floor elevation. METHODS: Twenty eight patients who planed to receive dental implant in the posterior maxilla underwent CBCT scan. After analysis of residual bone height, 19 patients with 5-10 mm bone height below the sinus floor underwent transcrestal sinus floor elevation, while 7 patients with less than 5 mm bone height below the sinus floor underwent lateral window sinus floor elevation. The treatment outcomes were assessed postoperatively. RESULTS: CBCT detected bone deficiency in the posterior maxillary alveolar bone in 26 patients, mucus cyst of maxillary sinus in 1 patient and sinus septa in 2 patients. Nineteen patients underwent transcrestal sinus floor elevation, and 7 patients underwent lateral window sinus floor elevation. All patients completed final dental restorations, and the restorations achieved satisfactory function and esthetic. CONCLUSIONS: CBCT imaging plays an important role in determining bone quality in posterior maxilla and guiding sinus floor elevation. Supported by Social Undertakings Technological Innovation and Demonstration Program of Nantong City (HS2011035).

[Clinical use of beta-tricalcium phosphate ceramics with patient's own bone in maxillary elevation with osteotome].

PURPOSE: To evaluate the clinical value of using the patient's autogenous bone mixed with beta-tricalcium phosphate ceramics(ß-TCP) for maxillary sinus lift with simultaneous implantation. METHODS: Patients with loss of posterior teeth and bone height of maxillary sinus floor between 4-10mm underwent internal sinus floor elevation, the proportion of bone to ß-TCP was 1:1 and the mixture was inserted into the sinus floor. All cases had simultaneously placed ITI implants.The final crown fabrication was taken 4-6 months after implanting. RESULTS: Twenty-one implants were inserted in 16 cases, the mean increase height was 4.2mm(2-6mm). There was clinical complaint of maxillary sinus inflammation in 1 case within 2 weeks, but the symptoms disappeared after antibiotic therapy. The remaining of 20 implants had no obvious complications. All implants had loaded for 32 months and were stable and well osseointegration on X-ray film. CONCLUSIONS: Maxillary sinus elevation with simultaneous implantation is an easy procedure. Implants can be stable for a long time.

[The application of lateral brow incision by the guide of sphenozygomatic suture for zygomatic complex fracture].

PURPOSE: To explore the application of lateral brow incision by the guide of sphenozygomatic suture for zygomatic complex fracture. METHODS: Lateral brow incision combined with intraoral vestibule incision and below cilia incision were applied in 26 patients who had Zingg's type B and C zygomatic complex fracture,through which the fracture lines around the forehead and zygomatic suture, sphenozygomatic suture, suborbital edge, zygomatic maxillary suture, zygomatic temporal suture, zygoma- alveolar column were exposed. After accurate reduction by the guide of sphenozygomatic suture, rigid fixation by titanium plates was performed. The patients were followed up for 3-24 months. RESULTS: Twenty-three patients acquired satisfactory outcome with ideal facial figure,function and minimal scar and 3 patients of type C developed mild asymmetric facial contour. CONCLUSIONS: The application of lateral brow incision by the guide of sphenozygomatic suture and rigid fixation for zygomatic complex fracture approach leaves minimal scar and injury to the facial nerve,with better esthetic and functional outcome.