ABSTRACT
A new ceramide urticamide (1), two new secolignans urticalactones I (2) and â ¡ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC50 values less than 4.0 µM.
Subject(s)
Plant Leaves/chemistry , Urticaceae/chemistry , Animals , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , China , Lipopolysaccharides/pharmacology , Magnetic Resonance Spectroscopy , Medicine, Chinese Traditional , Mice , Nitric Oxide/metabolism , Plant Extracts/chemistry , Plant Extracts/pharmacology , RAW 264.7 Cells , Tumor Necrosis Factor-alpha/metabolismABSTRACT
OBJECTIVE: To investigate the effect of a novel analgesic disposable urinary catheter invented by the authors in prevention of restlessness caused by catheter-related bladder discomfort (CRBD) in general anesthesia patients in anesthesia recovery period. METHODS: Two hundred patients, who underwent general anesthesia for general surgical operation, were divided randomly into 2 equal groups: observation group, undergoing insertion of F16 novel analgesic disposable Foley urinary catheter after inducement of general anesthesia, and control group undergoing insertion of conventional F16 Foley urinary catheter after induction of anesthesia. The rate of restlessness caused by CBRD and the rate of catheter pulling-off were compared. RESULTS: The CRBD rate of the observation group was 9%, significantly lower than that of the control group (61%, P < 0.01), the rate of CRBD-caused restlessness of the observation group was 0, significantly lower then that of the control group (23%, P < 0.001). The extent of CRBD of the observation group was significantly lighter than that of the control group. CONCLUSION: The catheter inserting after the induction of anesthesia is an element related to the restlessness in anesthesia recovery period and other serious postoperative complications. The novel analgesic disposable urinary catheter effectively prevents CRBD-caused restlessness in general anesthesia patients in the anesthesia recovery period.
