1.
Org Lett
; 25(3): 538-542, 2023 Jan 27.
Article
in English
| MEDLINE
| ID: mdl-36652331
ABSTRACT
Multi-component reaction of higher degree ultilization of diazo molecules for polyene formation is highly intriuging but still underexplored. We present herein an unprecedented coupling of 2,2,2-trifluorodiazoethane and aryl alkynes mediated by iodine under visible light. The multi-component reaction involving two diazo units and two alkyne units provides a straightforward and step-economic access to bistrifluoromethylated 1,3,5-trienes in high stereoselectivity by creation of three CâC bonds in a single step under mild conditions.