Travel bubble policies for low-risk air transport recovery during pandemics.

Global pandemics restrict long-haul mobility and international trade. To restore air traffic, a policy named "travel bubble" was implemented during the recent COVID-19 pandemic, which seeks to re-establish air connections among specific countries by permitting unrestricted passenger travel without mandatory quarantine upon arrival. However, travel bubbles are prone to bursting for safety reasons, and how to develop an effective restoration plan through travel bubbles is under-explored. Thus, it is vital to learn from COVID-19 and develop a formal framework for implementing travel bubble therapy for future public health emergencies. This article conducts an analytical investigation of the air travel bubble problem from a network design standpoint. First, a link-based network design problem is established with the goal of minimizing the total infection risk during air travel. Then, based on the relationship between origin-destination pairs and international candidate links, the model is reformulated into a path-based one. A Lagrangian relaxation-based solution framework is proposed to determine the optimal restored international air routes and assign the traffic flow. Finally, computational experiments on both hypothetical data and real-world cases are conducted to examine the algorithm's performance. The results demonstrate the effectiveness and efficiency of the proposed model and algorithm. In addition, compared to a benchmark strategy, it is found that the infection risk under the proposed travel bubble strategy can be reduced by up to 45.2%. More importantly, this work provides practical insights into developing pandemic-induced air transport recovery schemes for both policymakers and aviation operations regulators.

A Photosensitivity-Enhanced Plant Growth Algorithm for UAV Path Planning.

With the rise and development of autonomy and intelligence technologies, UAVs will have increasingly significant applications in the future. It is very important to solve the problem of low-altitude penetration of UAVs to protect national territorial security. Based on an S-57 electronic chart file, the land, island, and threat information for an actual combat environment is parsed, extracted, and rasterized to construct a marine combat environment for UAV flight simulation. To address the problem of path planning for low-altitude penetration in complex environments, a photosensitivity-enhanced plant growth algorithm (PEPG) is proposed. Based on the plant growth path planning algorithm (PGPP), the proposed algorithm improves upon the light intensity preprocessing and light intensity calculation methods. Moreover, the kinematic constraints of the UAV, such as the turning angle, are also considered. The planned path that meets the safety flight requirements of the UAV is smoother than that of the original algorithm, and the length is reduced by at least 8.2%. Finally, simulation tests are carried out with three common path planning algorithms, namely, A*, RRT, and GA. The results show that the PEPG algorithm is superior to the other three algorithms in terms of the path length and path quality, and the feasibility and safety of the path are verified via the autonomous tracking flight of a UAV.

Vulnerability of the worldwide air transportation network to global catastrophes such as COVID-19.

This paper studies the vulnerability of the worldwide air transportation network (WATN) during a global catastrophe such as COVID-19. Considering the WATN as a weighted network, many airport connections could be completely or partially disrupted during such extreme events. However, it is found that existing weighted metrics cannot reflect the impact of connection capacity reduction on network connectivity. Therein, this work proposes a novel network efficiency metric termed as layered weighted network efficiency (LWNE) metric to measure the connectivity of the air transportation networks (ATNs) and study their vulnerability in response to different levels of disruptions, including airport level, country level, and global level. The most critical airport connections and their impact on network connectivity are identified. It is found that the critical connections are mostly between so-called bridge airports but not core airports in the WATN. By examining the impact of partial link disruptions, it is found that some connections mainly serve local travel demand and are very robust to partial disruptions, while the others connecting global hubs are sensitive to partial disruptions. Further, the WATN is robust to the individual disconnection of most countries; however, it is vulnerable to the simultaneous disconnection of countries that serve international transfers. Interestingly, the WATN is insensitive to the disconnection between any two countries, even those with sizeable domestic ATNs. Concerning global disconnections, as long as all the international connections hold 10% of their original flights, the WATN can still expect 40% of its pre-disruption performance. This paper deepens the understanding of ATNs under extreme events and provides a method for studying transportation networks' vulnerability facing global disruptions.

Impact of entry restriction policies on international air transport connectivity during COVID-19 pandemic.

The COVID-19 pandemic has seriously impacted the air transport network (ATN) globally. Policies to restrict international passenger arrivals adopted by many countries are effective responses to control the spread of the virus. This paper studies the impact of two entry restriction policies implemented by some countries against international travelers during COVID-19, i.e., direct flight suspension and complete entry suspension, on the international connectivity (IC) of ATNs. Firstly, the concept of international air transport network (IATN) is defined, and a novel weighted IC index for ATNs is proposed considering flight frequency. Furthermore, to systematically analyze the difference between two policies, the hierarchical structure of the IATN is investigated, followed by studying the change of the IC index assuming different countries impose the two policies. Taking China as an example, this paper evaluates the influence of two policies based on real policy implementation of some countries against travelers from China. Besides, the critical countries affecting the IC are identified, and the network robustness is assessed. Implications for assessing and ranking the impact of different countries under different policies are provided and discussed. Lastly, two extensions are presented to discuss the impact of partial suspension and response actions such as air travel bubble. This work is one of the first to study the impact of country-to-country disconnection on air transport connectivity and deepens our understanding of the performance of ATNs during emergencies.

Spatiotemporal variation of the worldwide air transportation network induced by COVID-19 pandemic in 2020.

This paper studies the spatiotemporal variation of the worldwide air transportation network (WATN) induced by the COVID-19 pandemic in 2020. The variations are captured from four perspectives: passenger throughput, network connectivity, airport centrality, and international connections. Further, this work also considers both global and local connectivity-based metrics for the network analysis. Supported by real-world data, we show that the performance of the WATN has experienced a dynamic pattern of decline and recovery in 2020. Interestingly, the network metrics undergo tremendous variations in a very short period after the World Health Organization declared COVID-19 as a pandemic, with the number of flights and connections dropping by more than 40% within only the first four weeks. Intuitively, the passenger throughput's changing rate is highly correlated to confirmed cases' growth rate during the early period of the COVID-19 outbreak. However, the air transport response to the pandemic condition is very diverse among different countries. The major airports in the WATN fluctuate gradually in different pandemic stages, which is further influenced by the domestic pandemic situation that restricts airport operations. Also, the restoration speed of local connectivity is faster than that of global connectivity because the recovery of international aviation is geographically dependent on different policies of travel restriction, conditional openings, and the number of COVID-19 cases. The analysis deepens our understanding to formulate bilateral policies for pandemic-induced ATN design and management.

Heuristic Q-learning based on experience replay for three-dimensional path planning of the unmanned aerial vehicle.

In order to solve the problem that the existing reinforcement learning algorithm is difficult to converge due to the excessive state space of the three-dimensional path planning of the unmanned aerial vehicle, this article proposes a reinforcement learning algorithm based on the heuristic function and the maximum average reward value of the experience replay mechanism. The knowledge of track performance is introduced to construct heuristic function to guide the unmanned aerial vehicles' action selection and reduce the useless exploration. Experience replay mechanism based on maximum average reward increases the utilization rate of excellent samples and the convergence speed of the algorithm. The simulation results show that the proposed three-dimensional path planning algorithm has good learning efficiency, and the convergence speed and training performance are significantly improved.

Immunotoxic effects of thymus in mice following exposure to nanoparticulate TiO2.

Titanium dioxide nanoparticles (TiO2 NPs) have been extensively used in industry, medicine, and daily life, and have shown potential toxic effects for animals or humans. We noted that the effects of TiO2 NPs on the immune system and its mechanism of action in animals or humans have not been elucidated. Thus, mice were exposed to the TiO2 NPs (0, 1.25, 2.5, or 5 mg kg-1 body weight) for 9 consecutive months. Exposure to TiO2 NPs was accumulated in the thymus, leading to a decrease in body weight and increases in the weight of the thymus or thymus indices. In the blood, exposure to TiO2 NPs significantly decreased white blood cell, red blood cell, reticulocyte, haemoglobin, and mean corpuscular haemoglobin concentration; and increased mean corpuscular volume, mean corpuscular haemoglobin, platelets, and mean platelet volume. The reductions of lymphocyte subsets, including CD3+, CD4+, CD8+, B cell, and natural killer cell, were observed in the TiO2 NP-treated mouse thymus. Appearance of starry-sky aspect of the cortex that is given by the body of macrophages, bleeding, severe hemolysis or congestion, fatty degeneration, and cell apoptosis or necrosis were observed in the thymus following TiO2 NPs exposure. Importantly, TiO2 NPs increased expression of nucleic factor-κB(NF-κB), IκB kinase1/2, interleukin-1ß, interleukin -4, regulated upon activation normal T-cell expressed and secreted, cyclooxygenase 2, neutrophil gelatinase-associated lipocalin, purinergic receptors-7, interferon-inducible protein 10, hypoxia inducible factor 1-α, p-c-Jun N-terminal kinase, p-p38, and p-extracellular signal-regulated kinase 1/2 protein, respectively; whereas suppressed expression of IκB, peroxisome proliferater-activated receptor-γ, trefoil factor 1, peroxisome proliferator activated receptor gamma coactivator-1α, and prostaglandin E2 proteins in the thymus, respectively. Taken together, these results suggest that TiO2 NPs exerts toxic effects on lymphoid organs and T cell and innate immune cell homeostasis in mice and that these immunotoxic potential effects may result from the activation of NF-κB-mediated mitogen-activated protein kinases (MAPKs) pathway.

Robustness Assessment of Urban Road Network with Consideration of Multiple Hazard Events.

Robustness measures a system's ability of being insensitive to disturbances. Previous studies assessed the robustness of transportation networks to a single disturbance without considering simultaneously happening multiple events. The purpose of this article is to address this problem and propose a new framework to assess the robustness of an urban transportation network. The framework consists of two layers. The upper layer is to define the robustness index based on the impact evaluation in different scenarios obtained from the lower layer, whereas the lower layer is to evaluate the performance of each hypothetical disrupted road network given by the upper layer. The upper layer has two varieties, that is, robustness against random failure and robustness against intentional attacks. This robustness measurement framework is validated by application to a real-world urban road network in Hong Kong. The results show that the robustness of a transport network with consideration of multiple events is quite different from and more comprehensive than that with consideration of only a single disruption. We also propose a Monte Carlo method and a heuristic algorithm to handle different scenarios with multiple hazard events, which is proved to be quite efficient. This methodology can also be applied to conduct risk analysis of other systems where multiple failures or disruptions exist.

Nanoparticulate TiO2 -mediated inhibition of the Wnt signaling pathway causes dendritic development disorder in cultured rat hippocampal neurons.

Titanium dioxide nanoparticles (TiO2 NPs) are increasingly used in daily life, in industry, and in environmental clearing, but their potential neurodevelopmental toxicity has been highly debated. In this study, we explored whether TiO2 NPs inhibited development of dendritic morphology and identified possible molecular mechanisms associated with this inhibition in primary cultured rat hippocampal neurons. Results showed that TiO2 NPs decreased neurite length, the number of branches and the spine density, and impaired mitochondrial function in the developing neurons. Furthermore, TiO2 NPs significantly reduced the expression of several proteins involved in canonical Wnt3a/ß-catenin signaling including Wnt3a, ß-catenin, p-GSK-3ß, and CyclinD1 and conversely, elevated GSK-3ß expression. In addition to altering expression of proteins involved in canonical Wnt3a/ß-catenin signaling, TiO2 NPs decreased expression of proteins invovled in non-canonical Wnt signaling, including, MKLP1, CRMP3, ErbB4, and KIF17. Taken together, these results indicate that suppression of dendritic development caused by TiO2 NPs is associated with inhibition of activation of the Wnt/ß-catenin pathway or non-canonical Wnt pathway-induced expression of microtubule cytoskeletal components in the developing neurons. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2139-2149, 2017.

Toxic effects of TiO2 nanoparticles in primary cultured rat sertoli cells are mediated via a dysregulated Ca2+ /PKC/p38 MAPK/NF-κB cascade.

Although numerous studies have demonstrated that titanium dioxide nanoparticles (TiO2 NPs) can be accumulated in various animal organs and can cause toxicity, there is currently only limited data regarding reproductive toxicity especially on the toxic mechanisms of TiO2 NPs in Sertoli cells. In order to investigate the mechanism of reproductive toxicity, primary cultured rat Sertoli cells were exposed to 5, 15, or 30 µg/mL TiO2 NPs for 24 h, and TiO2 NPs internalization, expression of PKC (p-PKC) and p38 MAPK (p-p38 MAPK) as well as calcium homeostasis were examined. Our findings demonstrated that TiO2 NPs crossed the membrane into the cytoplasm or nucleus, and significantly suppressed cell viability of primary cultured rat Sertoli cells in a concentration-dependent manner. Furthermore, immunological dysfunction caused by TiO2 NPs was involved in the increased expression of NF-κB, TNF-α, and IL-1ß, and decreased IκB expression. TiO2 NPs significantly decreased Ca2+ -ATPase and Ca2+ /Mg2+ -ATPase activity and enhanced intracellular Ca2+ levels, and up-regulated the expression of p-PKC and p-p38 MAPK in a dose-dependent manner in primary cultured rat Sertoli cells. Taken together, these findings indicate that TiO2 NPs may induce immunological dysfunction of primary cultured rat Sertoli cells by stimulating the Ca2+ /PKC/p38 MAPK cascade, which triggers NF-κB activation and ultimately induces the expression of inflammatory cytokines in primary cultured rat Sertoli cells. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1374-1382, 2017.

Two solvent and temperature dependent copper(II) compounds formed by a flexible ligand: syntheses, structures and SC-SC transformation.

A nonporous neutral framework [CuCl(2)(m-bttmb)(2)](n) (1) was changed into a porous ionic {[Cu(m-bttmb)(2)(H(2)O)Cl]Cl(CH(3)CN)(0.5)(H(2)O)(2.75)}(n) (2) by simply increasing the amount of CH(3)CN in the mixed solvent (CH(3)CN and H(2)O) or temperature in the reactions of CuCl(2)·2H(2)O with 1,3-bis(triazol-1-ylmethyl)-2,4,6-trimethylbenzene (m-bttmb). 1 undergoes transformation into 2 when treated with CH(3)CN. Both 1 and 2 have 2D 4-connected (4,4) network architectures but in different packing arrangements. These compounds have been characterized by single-crystal X-ray diffraction analysis, elemental analysis, IR spectra and thermogravimetric analysis. This work may provide a way to control the formation of neutral or ionic frameworks, as well as porosities by adjusting the polarity and components of the solvents.

[Effects of different iron concentrations on the growths of a unicellular strain and a colonial strain of Microcystis aeruginosa].

We investigated the growth, photosynthetic efficiency, siderophore production and iron accumulation of two strains of M. aeruginosa, a unicellular strain M. aeruginosa PCC7806 and a colonial strain M. aeruginosa XW01, under iron-limited and iron-replete conditions. The identities of ITS and fur gene sequences of two strains were 95% and 98% respectively.That implied the two strains should be close relatives. Results showed the growths of two strains were severely inhibited under an iron-limited condition. The unicellular strain died in 6 days,whereas the colonial strain could maintain a weak growth in 10 days under the iron-limited condition. PSII maximum light energy transformation (Fv/Fm) of the colonial strain and the unicellular strain were 0.182 +/- 0.014 and 0.160 +/- 0.017, respectively. The colonial strain displayed a higher photosynthetic oxygen evolution than the unicellular strain. Two strains could produce siderophores, which were hydroxamate type. The colonial strain produced more siderophores than unicellular strain under the iron-limited condition.Iron contents of two strains were less than 1/3 cultured in the iron-limited condition than in iron-replete condition, but no obvious difference appeared between the two strains. Our result demonstrated that the colonial strain have a stronger endurance than unicellular strain under the iron-limited condition. As two strains had almost same abilities of iron accumulation, the other physiological mechanisms in the unicellular strain should be more sensitive to lower iron level.