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Article in Chinese | MEDLINE | ID: mdl-12744173

ABSTRACT

IL-8 was radiolabeled with 125I via Bolten-Hunter agent and the distribution of 125I-IL-8 in mice was determined in order to understand IL-8 behaviors in vivo. The percentage of 125I-IL-8 in blood, heart, liver, lung, kidneys, bone and spleen was obtained. The half-clearance of fast phase T1/2 alpha and slow phase T1/2 beta were 0.32 h and 8.01 h respectively. Most of 125I-IL-8 was excluded by kidneys.


Subject(s)
Interleukin-8/pharmacokinetics , Animals , Iodine Radioisotopes , Male , Mice , Recombinant Proteins/pharmacokinetics , Tissue Distribution
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