1.
Beilstein J Org Chem
; 8: 1233-40, 2012.
Article
in English
| MEDLINE
| ID: mdl-23019453
ABSTRACT
A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of ß-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification.