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[Synthesis of N,N-alkylene-bis-(substituted-phenol)glycine for removal of radio-actinides in rats].

Sun, M Z; Zhu, P E; Tang, C; Chen, A F; Shen, B Y.

Yao Xue Xue Bao ; 25(7): 505-8, 1990.

Article in Chinese | MEDLINE | ID: mdl-2085126

ABSTRACT

The synthesis of 16 compounds of N, N-alkylene-bis (substituted phenol) glycine is reported. They showed good effects on the removal of redinuclide thorium-234 from rats, except compound 3 and compound 4. Two of them can remove more than 70% of injected thorium. The relationship between structure and effects of these compounds was discussed.

Subject(s)

Glycine/analogs & derivatives , Phenols/chemical synthesis , Animals , Chelating Agents , Feces/chemistry , Glycine/chemical synthesis , Glycine/pharmacology , Phenols/pharmacology , Rats , Rats, Inbred Strains , Structure-Activity Relationship , Thorium/metabolism , Thorium/urine

[Studies on new antimalarials: synthesis of derivatives of benzo[b]1,5-naphthyridine].

Chen, C; Gao, F H; Zhu, P E; Zheng, X Y.

Yao Xue Xue Bao ; 17(5): 344-8, 1982 May.

Article in Chinese | MEDLINE | ID: mdl-7180466

Subject(s)

Antimalarials/chemical synthesis , Naphthyridines/chemical synthesis , Animals , Antimalarials/pharmacology , Mice , Naphthyridines/pharmacology , Structure-Activity Relationship

[Studies on new antimalarials--synthesis of heterocyclic compounds carrying double Mannich basic chains of p-aminophenol (author's transl)].

Chen, C; Zheng, X Y; Zhu, P E; Guo, H Z.

Yao Xue Xue Bao ; 17(2): 112-7, 1982 Feb.

Article in Chinese | MEDLINE | ID: mdl-7102319

Subject(s)

Antimalarials/chemical synthesis , Aminophenols , Animals , Antimalarials/pharmacology , Heterocyclic Compounds/chemical synthesis , Mannich Bases , Mice

[Synthesis of new antimalarial drug pyronaridine and its analogues (author's transl)].

Zheng, X Y; Chen, C; Gao, F H; Zhu, P E; Guo, H Z.

Yao Xue Xue Bao ; 17(2): 118-25, 1982 Feb.

Article in Chinese | MEDLINE | ID: mdl-7102320

Subject(s)

Antimalarials/chemical synthesis , Naphthyridines/chemical synthesis , Animals , Antimalarials/pharmacology , Mice , Naphthyridines/pharmacology

[Synthesis of organic salts of primaquine and experimental observations on their radical cure activity against malaria (author's transl)].

Chen, C; Zheng, X Y; Zhu, P E; Gao, F H; Huang, W Z; Ye, X Y; Pan, Y R; Luo, M Z; Yu, Q F.

Yao Xue Xue Bao ; 16(12): 897-901, 1981 Dec.

Article in Chinese | MEDLINE | ID: mdl-6803515

Subject(s)

Antimalarials/chemical synthesis , Malaria/drug therapy , Primaquine/analogs & derivatives , Animals , Antimalarials/therapeutic use , Chickens , Haplorhini , Mice

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