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Talanta ; 277: 126403, 2024 Sep 01.
Article in English | MEDLINE | ID: mdl-38878511

ABSTRACT

We have developed a convenient surface-enhanced Raman scattering (SERS) platform based on vertical standing gold nanowires (v-AuNWs) which enabled the on-mask detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related substances such as the Spike-1 protein and the corresponding pseudo-virus. The Spike-1 protein was clearly distinguished from BSA protein with an accuracy above 99 %, and the detection limit could be achieved down to 0.01 µg/mL. Notably, a similar accuracy was achieved for the pseudo-SARS-CoV-2 (pSARS-2) virus as compared to the pseudo-influenza H7N9 (pH7N9) virus. The sensing strategy and setups could be easily adapted to the real SARS-CoV-2 virus and other highly contagious viruses. It provided a promising way to screen the virus carriers by a fast evaluation of their wearing v-AuNWs integrated face-mask which was mandatory during the pandemic.


Subject(s)
COVID-19 , Gold , Masks , SARS-CoV-2 , Spectrum Analysis, Raman , Spectrum Analysis, Raman/methods , Gold/chemistry , SARS-CoV-2/isolation & purification , COVID-19/diagnosis , COVID-19/virology , Humans , Spike Glycoprotein, Coronavirus/analysis , Nanowires/chemistry , Limit of Detection , Surface Properties
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