Recent advances in Cu(II)/Cu(I)-MOFs based nano-platforms for developing new nano-medicines.

With increasing world population, life-span of humans and spread of viruses, myriad of diseases in human beings are becoming more and more common. Because of the interesting chemical and framework versatility and porosity of metal organic frameworks (MOFs) they find application in varied areas viz. catalysis, sensing, metal ion/gas storage, chemical separation, drug delivery, bio-imaging. This subclass of coordination polymers having interesting three-dimensional framework exhibits inordinate potential and hence may find application in treatment and cure of cancer, diabetes Alzheimer's and other diseases. The presented review focuses on the diverse mechanism of action, unique biological activity and advantages of copper-based metal organic framework (MOF) nanomaterials in medicine. Also, different methods used in the treatment of cancer and other diseases have been presented and the applications as well as efficacy of copper MOFs have been reviewed and discussed. Eventually, the current-status and potential of copper based MOFs in the field of anti-inflammatory, anti-bacterial and anti-cancer therapy as well as further investigations going on for this class of MOF-based multifunctional nanostructures in for developing new nano-medicines have been presented.

Recent developments on MOF-based platforms for antibacterial therapy.

With increasing pathogenic bacterial infection that is occurring worldwide, antibacterial therapy has become an important research field. There is great antimicrobial potential in the nanomaterial-based metal-organic framework (MOF) platform because it is highly biocompatible, biodegradable, and nontoxic, and it is now widely used in the anticancer agent industry and in the production of medical products. This review summarizes the possible mechanisms of representative MOF-based nanomaterials, and recounts recent progress in the design and development of MOF-based antibacterial materials for the remedy of postoperative infection. The existing shortcomings and future perspectives of the rapidly growing field of antimicrobial therapy addressing patient quality of life issues are also briefly discussed. Because of their wide applicability, further studies on the use of different MOF antimicrobial therapies will be of great interest.

Recent advances in MOF-based nanoplatforms generating reactive species for chemodynamic therapy.

Still today, cancer remains a threat to human health. Possible common treatments to cure this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and surgical resection, which give unreasonable results because of their limited efficiency and also lead to side-effects. Hence, different strategies are now being exploited to not only enhance the efficiency of these traditional therapeutic methods or treat the tumor cells but also curtail the side effects. A latest method with authentic proof of chemodynamic therapy (CDT) utilizing the Fenton reaction is now gaining importance. This approach, which is developed based on the high level of hydrogen peroxide (H2O2) in a tumor microenvironment (TME), can be used to catalyze the Fenton reaction to generate cancer cell-killing reactive oxygen species (ROS). The selection of materials is extremely important and nanomaterials offer the most likely method to facilitate CDT. Among various materials, metal-organic frameworks (MOFs) which have been extensively applied in medical areas are regarded as a promising material and possess potential for the next generation of nanotechnology. This review focuses on summarizing the use of MOFs in CDT and their synergetic therapeutics as well as the challenges, obstacles, and development.