[Biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration].

OBJECTIVE: To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration (GTR). METHODS: Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test, inserting the membrane into the rabbits, muscles, were employed to investigate its biocompatibility. RESULTS: Chitosan-carboxymethylchitosan blending membrane showed no toxicity. In early period after the insertion of the membrane, inflammatory processes with macrophages were observed, but the processes reduced with the membrane degradation. CONCLUSION: Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility.