ABSTRACT
Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.
Subject(s)
Bleomycin/toxicity , Collagen/metabolism , Lung/metabolism , Lung/pathology , Pulmonary Alveoli/metabolism , Pulmonary Alveoli/pathology , Pulmonary Surfactants/toxicity , Animals , Lung/drug effects , Male , Pulmonary Alveoli/drug effects , Rats , Rats, WistarSubject(s)
Pulmonary Surfactants/pharmacology , Respiratory Distress Syndrome/drug therapy , Amniotic Fluid/chemistry , Animals , Blood Gas Analysis , Bronchoalveolar Lavage Fluid/chemistry , Cattle , Dogs , Female , Humans , Lung/chemistry , Lung/drug effects , Lung/pathology , Mice , Microscopy, Electron , Phospholipids/analysis , Pregnancy , Pulmonary Surfactants/chemistry , Pulmonary Surfactants/toxicity , Rats , Respiratory Distress Syndrome/pathologyABSTRACT
As shown on the in vitro irradiated Ehrlich ascites tumor cells the increase in the intensity of ultraviolet fluorescence (UVF) of the exposed cells occurs only in such incubation conditions when an increase in the tryptophan content of irradiated cells becomes possible. The increase in the UVF intensity and in the tryptophan content are quantitatively identical. It is concluded that the increase in the content of the fluorescing substance, tryptophan, in the irradiated cells is the cause of the increase in the UVF intensity.
