Association of the C3953T (rs1143634) variant of the interleukin 1 beta gene with the features of a complicated course of COVID-19-associated pneumonia.

BACKGROUND: The pro-inflammatory cytokine IL-1 plays an important role in severe COVID-19. A change in IL-1 production may be associated with a mutation in the IL1Β gene. Our study analyzed the impact of the IL1Β gene variants (rs1143634) on disease progression in patients with severe COVID-19 pneumonia, taking into account treatment strategies. METHODS AND RESULTS: The study enrolled 117 patients with severe COVID-19 pneumonia. The IL1Β gene variants were identified using the polymerase chain reaction-restriction fragment length polymorphism method. In the group of patients, the following genotype frequencies were found based on the investigated rs1143634 variant of the IL1Β gene: CC-65.8%, CT-28.2%, and TT-6.0%. Our results showed that the group of patients with the T allele of the IL1Β gene had higher leukocyte counts (p = 0.040) and more pronounced lymphopenia (p = 0.007). It was determined that patients carrying the T allele stayed on ventilators significantly longer (p = 0.049) and required longer treatment with corticosteroids (p = 0.045). CONCLUSION: Identifying variants of the IL1Β gene can be used as a predictive tool for assessing the severity of COVID-19 pneumonia and tailoring personalized treatment strategies. Further research with a larger patient cohort is required to validate these findings.

[The role of social and economic factors in the formation of the somatic health level in school-aged children].

OBJECTIVE: Introduction: The article is devoted to a relevant problem - the state of health in school-aged children. Almost 90 % of school-aged children have deviations in their health, and over 50 % have poor physical fitness. Therefore, the problem of early diagnosis, detection and correction of pre-nosologic conditions is an effective means of preventing diseases and improving the health of children. The aim: The aim of the research was to examine the state of somatic health of school-aged children in Poltava and to identify the risk factors for its disturbances. PATIENTS AND METHODS: Materials and methods: We conducted the study of the state of physical health of 498 children aged 12-14 years in Poltava. The level of physical health was determined by the method of quantitative express-evaluation (G. L. Apanasenko) with the allocation of five levels of somatic health (low, lower than average, average, above average and high). To assess the relationship between the level of physical health and socio-economic factors, multiple correlation analysis and factor analysis were used. RESULTS: Results: It was found that in more than 60 % of adolescents, the level of somatic health was low and below average. According to the multifactor model, the level of physical health is positively influenced by the level of material wealth (ß = + 0.251), the level of mother's education (ß = + 0.295), the nutritional balance (ß = + 0.204), the time of stay in the fresh air (ß = + 0.106), and negatively - by the presence of harmful habits in parents (ß = -0.167). CONCLUSION: Conclusions: The conducted research allows us to consider the given social factors as determining in the formation of the level of health in the children's population. A comprehensive clinical examination of children, along with a quantitative determination of the level of somatic health, taking into account the socio-economic factors, will provide an opportunity to identify early signs of disorders in the adaptive mechanisms, to detect changes in the state of health at the pre-nosologic level and thus to take preventive measures in a timely manner.