ABSTRACT
The effects of thymic peptide (thymalin), bone marrow peptide (haemalin) and a complex compound (thymohaemin) on the haematopoiesis and immunity were studied in the experimental model of the induced haematopoiesis depression. Lymphopoiesis stimulation in the bone marrow was provoked by thymalin and granulopoiesis stimulation by haemalin. Simultaneously the restoration of a number of both T- and B-lymphocytes in the thymus was observed. Thymohaemin resulted in the restoration of practically all peripheral blood and bone marrow indexes as well as content of T- and B-lymphocytes in both central and peripheral immunogenetic organs. Likewise the use of the thymus and bone marrow peptide preparations facilitated the restoration of non-specific resistance which was evaluated by means of an integral index--lysosomal cation test. The results allow us to recommend the above preparations for a clinical trial in the haematopoiesis depletion.
Subject(s)
Bone Marrow , Hematopoiesis/drug effects , Hematopoietic Stem Cells/drug effects , Immune System/drug effects , Peptides/pharmacology , Thymus Gland , Adjuvants, Immunologic/pharmacology , Animals , Guinea Pigs , Hematopoiesis/radiation effects , Hematopoietic Stem Cells/cytology , Hematopoietic Stem Cells/radiation effects , Immune System/cytology , Immune System/radiation effects , Immunity, Cellular/drug effects , Immunity, Cellular/radiation effects , Intercellular Signaling Peptides and Proteins , Male , Thymus Hormones/pharmacology , Time FactorsABSTRACT
The investigation of parameters of hemograms, biochemical composition of blood, hemostasis, certain indicators of the immunological status in transfusing UV-irradiated autologous blood the authors made a conclusion that this variant of autohemotransfusion exerted a specific effect on the patient's organism. It depended on the scheme of irradiation of the blood, number of sessions of autotransfusions and intervals between them.