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Article in English | MEDLINE | ID: mdl-3449133

ABSTRACT

Following are the results of using the elaborated algorhythms of the structural analysis for the study of the form elements of the blood. A possibility was demonstrated to carry out a differential diagnosis of the familial hyperlipoproteidemia of the second type according to the quantitative structural parametres of the chromatin of the inter-phase nuclei of the lymphocytes of the peripheral blood. A method was developed of the automated morphometry of erythrocytes making it possible to assess the optical profile of erythrocytes according to 16 parametres. It was also registered a more vivid change of the curve of the membrane of the erythrocytes as compared with the Price-Jones spread on the same erythrocytes. With a help of a system of proposed parametres, which are 4-6-fold more informative and sensitive, than the traditional ones, it is possible to obtain the qualitatively new characteristics of the forms of erythrocytes, and not only their sizes.


Subject(s)
Cytodiagnosis/methods , Hyperlipoproteinemias/diagnosis , Chromatin/ultrastructure , Erythrocytes/ultrastructure , Humans , Hyperlipoproteinemias/blood , Hyperlipoproteinemias/genetics , Interphase , Lymphocytes/ultrastructure
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