ABSTRACT
The authors represent the results of the treatment of 20 children with Itsenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary body. The use of the medical proton beam of the Institute of Theoretical and Experimental Physics was found to be effective for the treatment of children with mild and average forms of ICD. Irradiation of the pituitary gland at a dose of 70-100 Gy is accompanied by general and local radiation reactions which are not dangerous for children. The time of development of remission after irradiation depends on a degree of severity and features of a course of disease.
Subject(s)
Cushing Syndrome/radiotherapy , Pituitary Irradiation/methods , Protons , Adolescent , Anthropometry , Child , Cushing Syndrome/diagnosis , Cushing Syndrome/epidemiology , Female , Follow-Up Studies , Humans , Male , Pituitary Gland, Anterior/metabolism , Pituitary Gland, Anterior/radiation effects , Pituitary Irradiation/adverse effects , Radiotherapy Dosage , Remission InductionABSTRACT
Forty children with Icenko-Cushing's disease were subjected to radiotherapy. Radiation of the pituitary with a proton beam in a dose of 70-100 Gy (7000-10000 rad) performed according to the indicated technique appeared highly effective. It was not associated with local or total radiation injuries and was safe. X-ray therapy conducted according to the fractionally intensive technique in a dose of 3000-3500 rad was less effective and produced disease relapses more frequently as compared with proton therapy.
Subject(s)
Cushing Syndrome/radiotherapy , Adolescent , Child , Female , Follow-Up Studies , Humans , Male , Radiotherapy Dosage , Recurrence , Time FactorsSubject(s)
Endocrinology/trends , Pediatrics/trends , Preventive Medicine/trends , Child , Humans , Infant, Newborn , Research , USSRSubject(s)
Cushing Syndrome/diagnosis , Osteoporosis/diagnosis , Adolescent , Child , Diagnosis, Differential , Humans , MaleSubject(s)
Lymphocytes/immunology , Thyroid Hormones/immunology , Adolescent , Child , Female , Humans , Male , Sex FactorsABSTRACT
The examination of 28 children with diffuse toxic goiter showed disturbance of glucose tolerance with a significant decrease in the level of C-peptide in the blood serum and its response to glucose. The concentration of immunoreactive insulin (IRI) and its increment under the influence of a glucose tolerance test in children was much above the normal. At the same time the molar C-peptide/IRI ratio in the patients' sera both on an empty stomach and during the glucose tolerance test showed a dramatic decrease indicating the reduction of insulin extraction by the liver as a cause of peripheral hyperinsulinemia. Distortion of the plasma immunoreactive glucagon reaction to a glucose tolerance test was observed in children with diffuse toxic goiter.
