ABSTRACT
Dilution of tribytylphosphate with normal paraffin, hexachlorbutadiene and trichlorobenzene does not change the pattern of plutonium distribution, but introduces some peculiarities in its dynamics. The lowest resorption of the radio element from the gastrointestinal tract was noted in the case of normal paraffins which, together with their low toxicity, makes this diluent preferable.
Subject(s)
Organometallic Compounds/pharmacokinetics , Organophosphates/pharmacokinetics , Organophosphorus Compounds/pharmacokinetics , Plutonium/pharmacokinetics , Solvents/pharmacokinetics , Absorption , Administration, Oral , Animals , Butadienes/administration & dosage , Butadienes/pharmacokinetics , Butadienes/pharmacology , Chlorobenzenes/administration & dosage , Chlorobenzenes/pharmacokinetics , Chlorobenzenes/pharmacology , Female , Organometallic Compounds/administration & dosage , Organophosphates/administration & dosage , Organophosphorus Compounds/administration & dosage , Paraffin/administration & dosage , Paraffin/pharmacokinetics , Paraffin/pharmacology , Plutonium/administration & dosage , Rats , Rats, Inbred Strains , Solvents/administration & dosage , Solvents/pharmacology , Stomach , Time Factors , Tissue Distribution/drug effectsABSTRACT
A study was made of the distribution of plutonium-239 within the rat body after single intragastric administration thereof (1.85 MBq) in a mixture with tributyl phosphate (TBP) and as Pu(IV) nitrate at a time interval from 4 min to 512 days. It was shown that the distribution of the radionuclide was virtually the same but its absorption from the gastrointestinal tract with Pu-TBP was higher by one order of magnitude and exceeded the value recommended by ICRP for soluble plutonium compounds.
Subject(s)
Nitrates , Organometallic Compounds/metabolism , Organophosphates/metabolism , Organophosphorus Compounds/metabolism , Animals , Intestinal Absorption/radiation effects , Male , Organometallic Compounds/administration & dosage , Organophosphates/administration & dosage , Organophosphorus Compounds/administration & dosage , Plutonium/administration & dosage , Plutonium/metabolism , Rats , Rats, Inbred Strains , Solutions , Stomach , Time Factors , Tissue Distribution/radiation effectsABSTRACT
Neptunium administered intravenously together with the high molecular weight protein fraction of blood serum was almost completely accumulated by the liver after 60 min. Then neptunium left the liver and was partially deposited in the skeleton. Plutonium, being a component of a nonprotein and a low molecular weight protein fractions, was mainly found in the skeleton where it had been accumulated throughout the entire period of observation (14 days, 52-58%); as to the nonprotein fraction, the value of accumulation was somewhat higher.
