1.
Neurosci Behav Physiol
; 39(2): 193-7, 2009 Feb.
Article
in English
| MEDLINE
| ID: mdl-19140003
Subject(s)
Cerebrovascular Disorders/complications , Cognition Disorders/etiology , Neuroprotective Agents/therapeutic use , Piracetam/therapeutic use , Aged , Ambulatory Care , Chronic Disease , Disease Progression , Female , Humans , Male , Middle Aged , Neuropsychological Tests , Severity of Illness Index
2.
Neurosci Behav Physiol
; 38(9): 933-6, 2008 Nov.
Article
in English
| MEDLINE
| ID: mdl-18975095
ABSTRACT
Despite the significant symptomatic effects of levodopa, stable 24-h treatment responses are in the vast majority of patients replaced 2-3 years from the start of treatment by oscillations in motor symptoms (fluctuation, dyskinesia), amelioration of which requires addition of constant (physiological) stimulation of postsynaptic dopamine receptors. To some extent this is provided by Stalevo, which contains levodopa and two enzyme inhibitors: the DDC inhibitor carbidopa and the COMT inhibitor entacapone. The results obtained in the present study demonstrated the advantages of Stalevo over traditional agents in patients with the "wearing off" and "on-off" phenomena.