[The characteristics of the antibiotic therapy of acute dysentery in an immunodeficiency body state in children with leukopenia]. / Osobennosti antibiotikoterapii ostroi dizenterii pri immunodefitsitnom sostoianii organizma u detei s leikopeniei.

Course of the disease and some indices of immunity were studied in 100 children with Sonne's and Flexner's dysentery. Parameters of immunity in 32 children (the 1st group) were normal. 68 patients (the 2-nd group) had secondary immune deficiency and leukopenia. Recovery of immunodeficient children in use of antibiotics and prodigiosan was slowed down by 5.2 days as compared to that of children without immunodeficiency. Antibiotics used in combination with lysozyme in patients of the 1st group resulted in restoration of immunological reactivity and recovery in usual terms.

[Antibiotic therapy of intestinal infections complicated by toxicosis and exicosis in children with immunodeficiency syndromes]. / Antibiotikoterapiia pri kishechnykh infektsiiakh, oslozhnennykh toksikozom i éksikozom u detei s immunodefitsitnym sostoianiem.

Clinical processes of acute intestinal infections complicated by toxicosis and exicosis and some host immunological parameters were studied in infants with secondary immunodeficiency. A special treatment scheme was developed including combined use of antibiotics, human immune globulin administered intravenously and cytochrome C. The scheme provided a decrease in the treatment duration by 8.6 +/- 1.1 days. Advanced and chronic diseases and fatal outcomes were absent. It was concluded that the developed scheme increased host immunological reactivity and efficacy of antibiotic therapy. It was recommended for wide clinical use in pediatric clinical care.

[Antibiotic therapy of acute dysentery in children with immunologic deficiency conditions]. / Antibiotikoterapiia ostroi dizenterii pri immunodefitsitnom sostoianii organizma u detei.

One hundred children with acute Sonnei and flexneri dysentery were followed up with respect to the infection process and main immunity indices. In 32 children the immunity indices were physiological (group 1) and in 68 children secondary immune deficiency was observed (group 2). The children were treated with aminoglycoside antibiotics and prodigiozan and it was stated that the time of recovery in the children with immune deficiency was longer by 5.2 days as compared to that in the children without immune deficiency. In the children with immune deficiency the combined use of one of the aminoglycosides, prodigiozan and lysozyme, led to a reduction of the host immunological reactivity and recovery within the same periods as those recorded for children with the physiological immunity status. It is recommended to use the antibiotic combination with prodigiozan and lysozyme in the treatment of all the forms of dysentery in children with secondary immune deficiency.

[Value of determining the spectrum of blood serum fatty acids in evaluating increasing the effectiveness of antibiotic therapy of dysentery in children with prodigiozan and ephedrine]. / Znachenie opredeleniia spektra zhirnykh kislot syvorotki krovi pri otsenke povysheniia èffektivnosti antibiotikoterapii prodigiozanom i efedrinom pri disenterii u detei.

One hundred and ninety one children with acute Sonne and Flexner dysentery were observed with respect to the disease process, immunity indices and blood serum fatty acid spectrum. 104 children were treated with monomycin alone and 87 children were treated with the antibiotic in combination with prodigiozan and ephedrine as immunostimulators. It was shown that the recovery terms in the patients treated with the use of the immunostimulators decreased as compared to the patients treated with the antibiotic alone. The fatty acid spectrum in the children treated with the use of the immunostimulators differed from that in the children treated without them by low levels of fatty acids of the C12:0 to C18:1 composition.

[Enhanced effectiveness of antibiotic therapy with an exogenous lysozyme in dysentery in children]. / Povyshenie éffektivnosti antibiotikoterapii ékzogennym lizotsimom pri dizenterii u detei.

The course of dysentery and the host immune responsiveness were studied in 171 children with acute Flexner's and Sonne dysentery. 67 children were treated with monomycin in combination with lysozyme and 104 children with monomycin alone. It was shown that the recovery period in children treated with monomycin and lysozyme was shorter as compared to that in children treated with monomycin alone. The immunity characteristics in children treated with monomycin were closer to the physiological values. It is concluded that lysozyme potentiates the antibiotic therapy in children with dysentery. It should be used combined with monomycin in the treatment of children irrespective of the age and the disease pattern. The treatment course with the use of monomycin in combination with lysozyme is reduced to 5 days.

[Effectiveness of tobramycin in young children with Salmonella infection]. / Effektivnost' tobramitsina pri sal'monelleznoi infektsii u detei rannego vozrasta.

The intestinal form of salmonellosis caused by S. typhimurium and the host immunity were studied in 108 infants. 60 infants were treated with ampicillin and the other 48 infants with tobramycin. The recovery period in patients treated with tobramycin was 8 days less as compared to the patients treated with ampicillin After discontinuation of the tobramycin use the pathogen was not detected in the repeated platings. Bactericidal function of neutrophils in these patients returned to normal within 15 days after the beginning of the treatment. Tobramycin was shown to be a highly active antibiotic in the treatment of salmonellosis of infants. No side effects were observed.