[Effect of the mineral-ammonia preparations MP-15 and MP-7 on nitrogen metabolism in cows]. / Vliianie mineral'no-ammoniinykh preparatov MP-15 i MP-7 na azotistyi obmen u korov.

It has been studied how MP-15 and MP-7 preparations fed on to lactating cows affect the indices of acid-base equilibrium of their blood, nitrogen metabolism, milk yield and milk quality. It is shown that feeding on MP-15 and MP-7 preparations to cows of test groups has no negative effect on the acid-base equilibrium indices, decreases the ammonia concentration by 38.5 and 54.9%, respectively, increases the glutamine content in blood by 23.5 and 29.4%, respectively, does not affect the pyruvate, glutamate, oxaloacetate concentration and alanine-transaminase activity, increases the average daily milk yields by 2.1 and 2.3 l, respectively, and does not deteriorate the composition and physicochemical indices of milk quality.

[Effect of carbostimulin on the concentration of tricarboxylic cycle metabolites, oxidative processes and antibody biosynthesis in the rat]. / Vliianie karbostimulina na soderzhanie metabolitov trikarbonovogo tsikla, okislitel'nye protsessy i biosintez antitel u krys.

Carbostimulin is studied for the effect it exerts on indices of the acid-base equilibrium of blood, content of certain tricarboxylic-cycle metabolites and free amino acids and formation of antibodies in rats. It is established that carbostimulin feeding increases the total carbon dioxide, pyruvate and lactate concentration in blood, the content of ammonium, glutamine and certain free amino acids being decreased. Oxidation processes in the liver mitochondria and biosynthesis of antibodies in experimental animals are shown to be more intensive than in the control ones.

[Effect of total content of carbon dioxide in blood biosynthesis of antipseudoplague antibodies in chickens]. / Vliianie obshchego soderzhaniia uglekisloty v krovi na biosintez protivopsevdochumnykh antitel u tsypliat.

The paper is concerned with a study of the sodium bicarbonate, carboxylin and hydrochloric acid effect on certain indices of acid-base balance in blood and on dynamics of antibody formation in chickens. The sodium bicarbonate or carboxylin feeding increases the carbon dioxide total content and intensity of antipseudoplague antibodies biosynthesis in the blood by 12-21 or 12.5-40%, respectively, as compared with the control. The hydrochloric acid feeding causes a decrease in the total amount of CO2 in the blood and inhibition of antibody formation by 12.7-32.8 % as compared with the control.

[Effect of tetanic anatoxin and carbonic acid level in blood on biosynthesis of antibodies in rats]. / Vliianie stolbniachnogo anatoksina i urovnia uglekisloty v krovi na obrazovanie antitel u krys.

The paper deals with dynamics of antibody formation in rats. Tetanic anatoxin independently of doses and methods of administration manifests weak immunogenic properties. A complete Freind adjuvant stimulates considerably the biosynthesis of antitetanic antibodies in the primary and secondary immune responses. Electrophoresis of tetanic anatoxin polyacrylamide gel permits isolating two protein fractions, one of them migrates in the immunoglobulin G zone and its mass constitutes 73%, the other-more low-molecular and contains 27% of protein. Dynamics of the acid-base blood state indices and of antibody biosynthesis is studied on models of chronic compensated alkalosis and metabolic acidosis in rats. It is established that during the experiment, simultaneously with an insignificant increase in the total carbonic acid concentration blood, there occurs a 25-60% increase in the titres of antitetanic antibodies as compared to the control. In rats with acidosis there occurs a simultaneously decrease in the intensity of antibody biosynthesis as compared to the control (43-54%) and in the total CO2 content in blood.

[Effect of carbonic acid of different concentrations of the glycolysis processes and tricarboxylic acid cycle in rat liver tissues]. / Vliianie razlichnykh kontsentratsii uglekisloty na protsessy glikoliza i tsikl trikarbonovykh kislot v tkani pecheni krys.

A rise in the carbonic acid and pH level in rat blood determines an increase in oxidative properties of the liver cell cytoplasm. Simultaneously the content of alpha-ketoglutarate, isocitrate, glutamate, alpha-glycerophosphate, dihydroxyacetone phosphate, pyruvate, lactate, malate increases and the level of glucose, glutamine and ammonia decreases. The in vitro experiments showed that the rise in the level of carbonic acid in the incubation medium from 10 up to 40 mM under all the studied values of pH (7.2, 7.4, 7.6) stimulates formation of dihydroxyacetone phosphate, malate, pyruvate, alpha-ketoglutarate (by 1.5-2.0 times). The same regularity is observed for lactate and glutamate at pH 7.4 and 7.6. The increase in the level of carbonic acid under the all studied values of pH produces a 1.5-fold decrease in the ammonia concentration.

[Suppression of hypersensitivity of the delayed and immediate types in guinea pigs by methylene diphosphonic acid]. / Ugnetenie metilendifosfonovoi kislotoi giperchuvstvitel'nosti zamedlennogo i nemedlennogo tipov u morskikh svinok.

The effect of methylene diphosphonic acid subcutaneous injection on delayed, as well as on the immediate hypersensitivity in guinea pigs was studied. It was shown that methylene diphosphonic acid (30 microgram/g) inhibited the delayed and immediate hypersensitivity by 60--80%, as compared to control animals.