ABSTRACT
The paper describes the clinical case of systemic Lupus Erithematosus in 14 year old boy with cerebral crisis of vascular origin, which developed during high immunological activity of pathological process. Adequate therapy with pulse-therapy was successful and had a good outcome for the patient.
Subject(s)
Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/drug therapy , Adolescent , Adrenal Cortex Hormones/therapeutic use , Diagnosis, Differential , Humans , Lupus Erythematosus, Systemic/complications , Male , Seizures/diagnosis , Seizures/drug therapy , Seizures/etiology , Treatment OutcomeABSTRACT
Reference data indicate on the important role of free radicals of nitrogen and oxygen in the mechanisms of the damage of cells and tissues during neonatal sepsis. Meanwhile these connections play an important role in protecting of the host organism from intervention of microorganisms. The aim of the study was the evaluation of peculiarities of oxidizing metabolism and containing of nitrogen oxide. Low consistence of nitrogen oxide and the disturbance of the intracellular oxidative-resorting balance during neonatal sepsis, especially in premature children, induces insufficiency of immune and antioxidant system, which changes the homeostasis and develops the oxidative stress of the host organism. As it was shown by the results of our study, antibacterial and supportive therapy doesn't provide the important reduction of processes of free radical oxidizing. The last circumstance makes a barrier for improving a clinical condition of the newborns.
Subject(s)
Nitrogen/metabolism , Oxygen/metabolism , Sepsis/metabolism , Gestational Age , Humans , Infant, Newborn , Infant, Premature , Nitric Oxide Synthase/metabolism , Sepsis/enzymologyABSTRACT
The Osteogenesis imperfecta (OI) is a hereditary disturbance of collagen biosynthesis. The illness is characterized by frequent fractures that consequently cause functional disturbance of locomotion system as well as deformation of long tubular bones. The purpose of the present work was to study radiological features of clinical forms of osteogenesis imperfecta during bisphosphonate treatment in children according to the schemes we developed taking into consideration the type of illness and the age of the patient. The total number of 32 patients, aged 1-15, suffering from osteogenesis imperfecta, have been investigated. The patients have been divided into three groups depending on the type of illness (I, III and IV type). Type II (lethal form) has not been observed by us. All patients, participating in the study underwent radiological examination of tubular bones and vertebra pre and post treatment. The results of the study showed that bisphosphonate treatment has positive effects in patients of type I and IV of osteogenesis imperfecta and is less effective in the type III of the diseases.
Subject(s)
Bone Density Conservation Agents/therapeutic use , Diphosphonates/therapeutic use , Osteogenesis Imperfecta/diagnostic imaging , Osteogenesis Imperfecta/drug therapy , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Pamidronate , Tomography, X-Ray ComputedABSTRACT
The aim of the study was the comparison of clinical, laboratory end instrumental data between systemic lupus erythematosus (SLE) end infectious endocarditis (IE) for analysis of similar and different features. Clinical, laboratory and instrumental data were analysed and compared for 96 SLE and 23 IE patients. SLE and IE have the following common features: fever, pleurisy, pericarditis, myocarditis hemorrhagic vasculitis, renal disorders, anaemia, concentrations of circulating immune complex (CIC), IgM. Characteristic of SLE were skin erythema, alopecia, cerebrovasculitis, lymhadenopathy, pneumonitis, frequent articular lesions, pancytopenia, high IgG levels, and antibodies to DNA. After echocardiographic investigations a rare revelation of the damage of endocardium, and the lack of destruction of the valve were detected. IE was characterized by thromboembolic complications, splenomegaly, pneumonia, high IgM levels, high incidence rate of RF, positive hemoculture. By echocardiographic studies bacterial vegetations end valvular pathology were detected. These data gives us the possibility for early differential diagnostics of these two diseases.
Subject(s)
Endocarditis, Bacterial/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Adolescent , Antibodies, Anti-Idiotypic/immunology , Antibodies, Antinuclear/immunology , Biomarkers/blood , Child , Child, Preschool , Diagnosis, Differential , Echocardiography , Endocarditis, Bacterial/blood , Endocarditis, Bacterial/immunology , Female , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Lupus Erythematosus, Systemic/blood , Lupus Erythematosus, Systemic/immunology , Male , PrognosisABSTRACT
14 children with reactive arthritis (ReA) were treated by antibiotics of macrolid group--vilprafen and anti-inflammatory medicines. Immunocorrective mean ronkoleukin (recombinant interleukin-2) was used as an additional therapy for activation of lymphocytes and NK cells. Five patients from 14 were treated by intravenous injections of ronkoleukin followed by oral administration of this drug. 9 children were treated by oral administration of ronkoleukin. All 14 children were treated by ronkoleukin along with the basic therapy. All children got repeated course of ronkoleukin one year later. From 14 children 12 reached remission of the disease.
Subject(s)
Analgesics, Non-Narcotic/therapeutic use , Arthritis, Reactive/drug therapy , Chlamydia Infections/drug therapy , Interleukin-2/therapeutic use , Administration, Oral , Adolescent , Analgesics, Non-Narcotic/administration & dosage , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antibodies, Bacterial/analysis , Antigens, CD/blood , Arthritis, Reactive/diagnosis , Arthritis, Reactive/immunology , Child , Child, Preschool , Chlamydia Infections/diagnosis , Chlamydia Infections/immunology , Enzyme-Linked Immunosorbent Assay , Humans , Immunoglobulin A/blood , Immunoglobulin G/blood , Immunoglobulin M/blood , Injections, Intravenous , Interleukin-2/administration & dosage , Prohibitins , Recombinant Proteins/administration & dosage , Recombinant Proteins/therapeutic use , Remission Induction , Time Factors , Treatment OutcomeABSTRACT
Pathogenic mechanism of acute and chronic inflammation is connected to the increased production of superoxide anion, hydrogen peroxide, and other free radicals. Clinical role of lipid peroxidation (LPO) processes was studied in 38 patients in the age from 3 to 15 years old with different variants of Rheumatic Fever (RF). We have investigated the relationship between malonidialdehide (MDA) and RF. We measured the levels of MDA in the plasma in patients with acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD). Our study revealed that the levels of MDA in patients with ARF are significantly higher than in patients with CRHD. These levels were also significantly higher in patients with history of disease for up to 2 years, than in patients with history longer than 2 years. Thus, the measurement of MDA in the plasma could be used as a laboratory test for relation of active state of rheumatic fever.
Subject(s)
Lipid Peroxidation , Malondialdehyde/blood , Rheumatic Fever/metabolism , Rheumatic Heart Disease/metabolism , Adolescent , Age Factors , Child , Child, Preschool , Data Interpretation, Statistical , Diagnosis, Differential , Humans , Rheumatic Fever/blood , Rheumatic Fever/classification , Rheumatic Fever/diagnosis , Rheumatic Heart Disease/blood , Rheumatic Heart Disease/diagnosis , Time FactorsSubject(s)
Dermatomyositis/diagnosis , Adolescent , Child , Dermatomyositis/classification , Dermatomyositis/mortality , Female , Humans , Male , PrognosisSubject(s)
Dermatomyositis/classification , Acute Disease , Child , Chronic Disease , Dermatomyositis/diagnosis , Humans , Recurrence , Remission, SpontaneousSubject(s)
Dermatomyositis/diagnosis , Child , Dermatomyositis/blood , Dermatomyositis/urine , HumansSubject(s)
Dermatomyositis/diagnosis , Skin/blood supply , Adolescent , Child , Female , Humans , Male , Plethysmography, ImpedanceSubject(s)
Dermatomyositis/pathology , Respiratory Insufficiency/pathology , Adolescent , Autopsy , Child , Child, Preschool , Female , Humans , Infant , Male , Pneumonia/pathologyABSTRACT
The ultrastructure of skeletal muscles was studied on 6 bioptates collected from children with the idiopathic form of dermatomyositis. The main type of the affection of muscle fibers was myolysis the intensity of which correlated with the degree of activity of the disease. In focal myolysis, signs of intracellular regeneration were found in fibers. Diffuse myolysis was characterized by retained hypertrophic nuclei and basal membranes of sarcolemma against the background of complete degeneration of myofibrillae and a sharp decrease in the fiber diameter. Considerable hyperplastic changes in myosatellitocytes were found, but with no regenerating fibers, however. The permanent features included hypertrophic and dystrophic changes in the vascular endothelium and pericytes. In the maximally active disease, destruction of capillaries and a decrease in their numbers were found. Microtubular structures and nuclear bodies were found in the endothelium, pericytes, and less frequently in other cells.
