[The morphogenesis of intramedullary cavities and of a glial-connective tissue cicatrix and the enzyme status of the proteolytic system in experimental spinal cord trauma]. / Morfogenez intramedulliarnykh polostei, gliosoedinitel'notkannogo rubtsa i sostoianie fermentov sistemy proteoliza pri éksperimental'noi travme spinnogo mozga.

Canine and feline experiments were conducted to study the morphology of intramedullary cavities and a glial connective tissue cicatrix, their roles in the spinal regenerative processes as compared with the altered activity of trypsin and proteolytic inhibitors in spinal fluid and serum in different periods after spinal dissection. It was shown that decreased diastasis between the ends of the cut spine, enclosure of a traumatic area from liquor of the subarachnoidal space and central canal reduced the number and area of cavities in the cerebral cicatrix and contributed to improved regeneration of intraspinal fibers. Spinal injury caused a significant increase in trypsin and to changes of the antiprotease activity of inhibitors, spinal fluid, particularly in early postoperative periods.

[Radiography as a criterion for evaluation of treatment results in chronic hematogenic osteomyelitis of the long bones]. / Rentgenografiia kak kriterii otsenki rezultatov lecheniia khronicheskogo gematogennogo osteomielita dlinnykh kostei.

The findings of roentgenologic observation of the patients for 4 years after plasty of the residual cavity of dura mater of the brain are presented. A good long-term result was noted in 85.7% of the patients.

[Mechanism of formation of intramedullary cavities and their role in the regeneration of the spinal cord]. / Mekhanizm obrazovaniia intramedulliarnykh polostei i ikh rol' v protsesse regeneratsii spinnogo mozga.

The spinal cord preparations of 38 dogs and 20 rabbits have been studied with the aim to investigate the influence of the cerebrospinal fluid on the spinal cord nervous tissue. The spinal cord preparations of 8 patients having trauma of the vertebral column with interruption of the spinal cord have also been studied. As demonstrate histological investigations, the cerebral tissue of the pieces, put into the flask with liquor, in the subarachnoidal space of the canine spinal cord, in diastasis between the ends of the cut spinal cord during 6 h up to 7 days, swells, becomes edematous. Cavities occupying about 30% of the area in the slices studied appear in it. At hemisection of the rabbit spinal cord without closure of the defect in the meninx vasculosa with the glue MK-6, the area of the cavity formation varies from 24 up to 35%, comparing the whole area of the preparation, while in rabbits with hemisection and successive gluing of the defect in the meninx vasculosa the area of the nervous tissue destruction makes 13-18%. It has been proved that the scar forming in the traumatized segment of the spinal cord does not present a continuous formation, but contains a large amount of cavities that prevent regeneration of nerve fibers. The experimental data concerning lysing effect of the cerebrospinal fluid on the traumatized nervous tissue are confirmed by the results obtained at investigating the preparations of the spinal cord of the patients died as the cause of the spinal cord trauma.

[Clinico-morphologic analysis of traumatic disease of the spinal cord]. / Kliniko-morfologicheskii analiz travmaticheskoi bolezni spinnogo mozga.

The clinical findings in 8 spinal patients were compared with the morphological changes in the spinal cord and peripheral nervous system revealed postmortally. The study disclosed clinico-morphological parallels and peculiarities of the dystrophic processes in the tissues in the course of traumatic disease of the spinal cord.

[Histochemical characteristics of the neural apparatus of the bronchi in different states of tonus]. / Gistokhimicheskie osobennosti nervnogo apparata bronkhov pri razlichnom sostoianii ikh tonusa.

Composite histoenzymochemical characteristics of the nervous apparatus of bronchi in vagotomy, desympathetization, histamine shock, and development of pneumonia experimentally and clinically were obtained. The development of bronchospasm under the above effects and in pneumonia was found to be accompanied by decreases in the activity of acetylcholinesterase, the content of noradrenaline, a high content of nucleoproteins, polysaccharides, a high activity of oxidoreductases in different structures of the nervous apparatus of the bronchi. Bronchodilatation was accompanied by a decrease of all the above-mentioned indicators of the status of the nervous apparatus as well as destructive changes in its elements. The condition of production and utilization of the cholinergic and adrenergic mediators is discussed on the basis of the data obtained.

[Structure and physicomechanical properties of the human dura mater from the age aspect]. / Stroenie i fiziko-mekhanicheskie svoistva tverdoi mazgovoi obolochki cheloveka v vozrastnom aspekte.

The reconstructive surgery embracing a wide range of operations, when the dura mater is used as plastic material, requires a profound study of its physico-mechanical and structural properties. The dura mater obtained from 150 human corpses of persons at the age of 1 month of embryogenesis up to 90 years has been studied by means of morphological, histochemical methods and using the device for mechanical testing of various biological materials. In ontogenesis of the dura mater three states are arbitrary distinguished: development, stabilization of morphological structures and involutional-degenerative changes. Specific feature of each stage are described. Owing to the investigations performed, it is possible to state optimal time range for taking transplants and widening the limits for choosing for plastic material with the reference to the required strength, thickness,, stretching and elasticity.

[Changes in vessels of the microcirculatory bed following parenteral administration of xenogeneic cerebrospinal fluid obtained in vivo to normal animals and animals with experimental hypercholesterolemia]. / Izmeneniia sosudov mikrotsirkuliatornogo rusla pri parenteral'nom vvedenii prizhiznenno poluchennoi ksenogennoi spinnomozgovoi zhidkosti v usloviiakh normy i pri éksperimental'nom giperkholesterinemii.

Effect of parenteral administration of xenogenic liquor, vitally obtained, on the state of the microcirculatory bed, as well as its biostimulating action for cellular metabolism activation have been studied. The number of actively functioning capillaries increases, microvessels dilate, vascular permeability intensifies not only under normal conditions, but under experimental hypercholesteremia, as well. How the changes observed in the microcirculatory bed depend on various doses and total amount of the preparation administered, as well as means of its conservation have been analysed and stated. The dynamics of indices on lipid metabolism have been studied.

[Experimental-morphological reasons for using dura mater for plastic surgery of defects of the anterior abdominal wall]. / Eksperimental'no-morfologicheskie obosnovaniia k peimeneniiu tverdoi mozgovoi obolochki dlia plastiki defektov perednei briushnoi stenki.

A possibility to use preserved dura mater (in 2% formalin) for substituting various abdominal wall layers under both sterile and infectious conditions has been studied experimentally in 126 dogs. Morphological investigation has been performed at various postoperative time (1 day--2 years). It has been stated that the dura mater implantation produces minimal aseptic inflammatory reaction in the abdominal wall tissues. The transplant is gradually disorganized and resolved and simultaneously substituted with the connective tissue. There are no commissurae between the transplant and the abdominal organs. The dura mater is resistive to infections. Application of the dura mater for surgery of hernia of the abdominal wall is substantiated.

[Prevention of asphyxia in tracheomalacia after operations of the thyroid gland]. / Preduprezhdenie asfiktsii pri trakheomaliatsii u bol'nykh posle operatsii na shchitovidnoi zheleze.

A new technique for prevention of asphyxia in tracheomalacia has been developed. The technique consists in suturing the softened portion of the trachea to the dura mater graft which had been previously fixed to its healthy portions. Such a technique allows performing reliable fixation of the tracheomalacia portion in an extended state and thereby to prevent asphyxia, The technique was used in 11 operated patients and gave good results.