Polymorphism Pro12 --Ala of the peroxisome proliferator-activated receptors gamma gene effect on lipid peroxidation and antioxidant defense in patients with type 2 diabetes.

In this research, we discover effect ofpolymorphism rs1801282 of the PPARG gene on the formation oxidative stress in patients with type 2 diabetes, depending on the duration of the disease: till 5 years, 5-10 years and more than 10 years. Activity of lipidperoxidation was assess in terms of diene conjugates (DC) and malonic dealdehid (MDA) and antioxidant system status - the activity of superoxide dismutase (SOD), catalase and the level of a-tocopherol (a-TF). Molecular genetic studies conducted by the method ofpolymerase chain reaction (PCR) in real time. During disease 5-10 years, found increase levels of DC and MDA in patients with polymorphism Pro12--Ala for 34.9 and 34.7%, in compared with ProPro12 --Pro (P=O. 01). Availability ProPro12 --Pro stipulated reduction of catalase activity during disease 5-10 years at 75% (P=O. 001), andfor those, who are illfor more than 10 years at 2,04 times (P=O.01), which is not different from the reference level (F=1. 19; P=O. 600), but in the case ProPro12 --Ala, this figure was in 2 times higher The main conclu- sion is that the type ProPro12 --+Ala ofpolymorphism rs1801282 of the PPARG gene causes the development of oxidative stress in patients with type 2 diabetes with 5-10 years durations, and Pro Pro12 --Pro - deficiency the enzyme catalase level of antioxidant system in patients with durations of disease more than 5 years.

[The characteristics of individual reactions of the central hemodynamics to trauma]. / Osoblyvosti indyvidual'nykh reaktsii tsentral'noï hemodynamiky na travmu.

Experiments with white mongrel male rats subjected to the standard trauma according to Kennon have revealed four types of responses of the central haemodynamics. The minimal mortality rate (31-38% for the first three days) was registered for hyper- and eudynamic types when the heart productivity parameters and atmospheric pressure either exceeded or were almost similar to those of intact animals. A decrease of these parameters (a hypodynamic type) has led to increase of the mortality rate (to 58%), but a sharp (more then 3 times) decrease of the cardiac index was characterized by a progressive increase of the arterial pressure and maximal mortality rate.

[The cyclic nucleotide content of the blood plasma in rabbits administered izadrin]. / Vmist tsyklichnykh nukleotidiv u plazmi krovi krolykiv pry vvedenni izadrynu.

The influence of cyclic nucleotides system on the rabbit resistance to injection of exogenic sympathomimetic was studied in this experiment. Absolute concentration value and ratio of cAMP to cGMP in animals with different resistance were determined.