ABSTRACT
BACKGROUND: The first step toward organizing research activities is to obtain a correct perception of available capabilities. This study was conducted to investigate the researchers' views about barriers affecting research activities. METHODS: This descriptive, cross-sectional study was conducted using the census method. The population consisted of the faculty members of Birjand University of Medical Sciences in 2014. The research tool was a questionnaire in six areas of financial, facility, professional, scientific, personal, and organizational- managerial barriers. The results were analyzed using descriptive statistics and Friedman test. RESULTS: Faculty members confirmed that although all barriers affected research activities, organizational-managerial barriers (3.73 ± 0.63) had the greatest and scientific barriers (3.15 ± 0.93) had the lowest effect, respectively. The results of Friedman test showed that there is a significant difference between the mean values of factors related to various barriers affecting research activities from the viewpoint of the participants' answers. CONCLUSIONS: Research activities are affected by numerous barriers. Strategies, such as empowering researchers, employing new technologies in the creation of research teams, and benefiting from research experts in various stages of research, may have a positive effect on the removal of the barriers.
ABSTRACT
Periodontitis (PD) is known to be one of most prevalent worldwide chronic inflammatory diseases. There are several treatments including antibiotics for PD; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. The effects of trans-anethole on IL-1 ß and TNF-α level in a rat model of PD were investigated and compared to ketoprofen. Eschericia coli lipopolysaccharide (LPS, 30 µg) was injected bilaterally into the palatal gingiva (3 µL/site) between the upper first and second molars every two days for 10 days in anesthetized rats. Administration of either trans-anethole (10 or 50 mg/Kg, i.p.) or ketoprofen (10 mg/Kg, i.p.) was started 20 minute before LPS injection and continued for 10 days. Then, IL-1ß and TNF-α levels were measured in blood samples by ELISA at day 0 (control) and at day 10. Anethole at both concentrations significantly suppressed IL-1ß and TNF-α production when compared to LPS-treated rats. The suppressive effects of anethole on LPS-induced pro-inflammatory cytokines were almost similar as seen with ketoprofen. In conclusion, the present results suggest that anethole may have a potent inhibitory effect on PD through suppression of pro-inflammatory molecules; therefore it could be a novel therapeutic strategy for PD.
