ABSTRACT
The concomitant finding of hypogonadotropic hypogonadism and temporal lobe epilepsy raises the issue of whether or not these entities are related. The case presented herein is one such example. The possible pathophysiologic basis of infertility and temporal lobe epilepsy is reviewed.
Subject(s)
Epilepsy, Temporal Lobe/complications , Hypogonadism/complications , Adult , Epilepsy, Temporal Lobe/physiopathology , Follicle Stimulating Hormone/blood , Humans , Hypogonadism/physiopathology , Infertility, Male/etiology , Infertility, Male/physiopathology , Luteinizing Hormone/blood , Male , Testosterone/bloodABSTRACT
Interleukin-2-stimulated lymphocytes or lymphokine-activated killer cells (LAK) have been shown to have anti-tumor activity which is not present in the fresh untreated peripheral blood lymphocytes. This activity has been evaluated in our laboratory using renal cell carcinoma as a target tumor. Two of 8 patients demonstrated significant lysis of autologous tumor while an additional 3 patients lysed the target cells but to a less significant degree. It is not clear why the LAK phenomenon against autologous tumors occurs in vitro in some patients and not others. By identifying the response of patients in vitro, one might be able to select an appropriate population for meaningful clinical trials.
Subject(s)
Carcinoma, Renal Cell/immunology , Immunization, Passive , Interleukin-2/immunology , Kidney Neoplasms/immunology , Killer Cells, Natural/immunology , Lymphocytes/immunology , Cell Line , Female , Humans , In Vitro Techniques , Male , Tumor Cells, CulturedABSTRACT
The association of neural crest tumors with myoclonic encephalopathy of infants has been well described. Since these tumors often are clinically occult the diagnostic modalities used to identify these lesions need to be sensitive. We describe a child with neuroblastoma associated with infantile myoclonic encephalopathy in whom magnetic resonance imaging identified the lesion while other techniques were unable to demonstrate a mass clearly. Magnetic resonance imaging should be considered as a diagnostic modality when adrenal lesions are suspected but not apparent with other imaging techniques.
