1.
Farmakol Toksikol
; 40(5): 578-82, 1977.
Article
in Russian
| MEDLINE
| ID: mdl-923780
ABSTRACT
The effectiveness of immunodepressants in lingering exudative processes, their inhibitory action in the proliferative phase of inflammation, depression of the phagocytic activity of leucocytes, as well as suppressive influence on the development of a toxic pulmonary edema and upon generalized anaphylaction reaction was demonstrated in tests staged on rats and mice. The antiphlogistic action of immunodepressants was not abolished during the first hours after their administration by specific metabolites, but was suppressed at the peak of the cytostatic effect together with the latter. The phlogolytic effect was not mediated through the hypophysis-adrenal system and did not include the lienic factor.
Subject(s)
Anti-Inflammatory Agents , Immunosuppressive Agents/therapeutic use , Anaphylaxis/drug therapy , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug Therapy, Combination , Fluorouracil/therapeutic use , Granuloma/drug therapy , Mercaptopurine/therapeutic use , Methotrexate/therapeutic use , Phagocytosis/drug effects , Pulmonary Edema/drug therapy , Rats , Time Factors
2.
Farmakol Toksikol
; 32(1): 102-5, 1969.
Article
in Russian
| MEDLINE
| ID: mdl-4388892
Subject(s)
Insecticides/poisoning , Miotics/poisoning , Parasympatholytics/therapeutic use , Phosphates/poisoning , Vitamins/therapeutic use , Acute Disease , Animals , Anura , Ascorbic Acid/therapeutic use , Atropine/therapeutic use , Drug Synergism , Female , Ganglionic Blockers/therapeutic use , Insecticides/antagonists & inhibitors , Male , Mice , Niacinamide/therapeutic use , Pyridoxine/therapeutic use , Rabbits , Riboflavin/therapeutic use , Thiamine/therapeutic use , Vitamin B 12/therapeutic use , Vitamin K/therapeutic use
3.
Farmakol Toksikol
; 31(5): 571-4, 1968.
Article
in Russian
| MEDLINE
| ID: mdl-5707727
4.
Sov Med
; 29(9): 61-3, 1966 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-5993705