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Vopr Onkol ; 23(4): 61-5, 1977.
Article in Russian | MEDLINE | ID: mdl-883197

ABSTRACT

Chloroprene (2-chlorobutidiene 1,3) is an intermediate chemical product derived in the process of obtaining synthetic rubber. Chloroprene was shown by the experiments on mice and rats to be not carcinogenic. The application of chloroprene in animals by skin smears, subcutaneous injections, per os and intratracheal administration failed to induce any tumors in the experimental animals. No tumors were observed also in animals after using its combination with very small doses of dimethylbenz (a) anthracene.


Subject(s)
Butadienes/analogs & derivatives , Carcinogens , Administration, Oral , Aerosols , Animals , Butadienes/administration & dosage , Butadienes/toxicity , Drug Evaluation , Female , Injections, Subcutaneous , Male , Mice , Rats , Trachea
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