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Endocrinology ; 98(1): 176-8, 1976 Jan.
Article in English | MEDLINE | ID: mdl-1248441

ABSTRACT

Perfusion of the thyro-parathyroid glands in the dog with calcium-rich blood led to a significant decrease (P less than 0.001) in the systemic plasma calcium level. On the other hand, injection of reserpine (0.2 mg/kg ip) 16 and 2 h prior to infusion of hypercalcemic blood into thyro-parathyroid glands did not alter the systemic plasma calcium level significantly (P less than 0.05). This result provides evidence that reserpine blocks the release of hypocalcemic factor from the thyro-parathyroid glands in response to perfusion of high concentrations of calcium.


Subject(s)
Calcium/blood , Parathyroid Glands/physiology , Reserpine/pharmacology , Thyroid Gland/physiology , Animals , Dogs , Female , Hypercalcemia/blood , Male , Perfusion , Pulse/drug effects
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