[A missing link in classification of occupational pulmonary diseases--occupational chronic obstructive lung diseases]. / O nedostaiushchem zvene v klassifikatsii professional'nykh zabolevanii legkikh--professional'noi khronicheskoi obstruktivnoi bolezni legkikh.

The authors justified a suggestion on including chronic obstructive lung diseases (COLD) into Occupational Diseases Register.

[Radiosensitization effect of taxol on malignant tumor cells]. / Radiosensibilizuiuchii efekt taksolu na klitini zloiakisnikh pukhlin.

Radiosensitizating abilities of taxol have been investigated in vitro using L929 cells and in vivo Geren carcinoma (T-8 cell line). Radiosensitizating effect of taxol was detected for the both cell lines. Pathologic mitoses have been also analyzed and increasing of abnormal mitosis total level was observed. It is supposed that this phenomenon could determine radiosensitizating abilities of taxol.

[Biochemical mechanisms of acquired radioresistance of tumor tissue]. / Biokhimicheskie mekhanizmy priobretennoi radiorezistentnosti opukholevoi tkani.

The level of lipoperoxidation products in radioresistant tumour is 3 times lower and superoxide dismutase activity--3.5 times higher than in the intact tumour. That is an evidence of high stability. The level of lipoperoxidation products in the brain and liver of rats with radioresistant variant of Guerin carcinoma is essentially less and catalase activity--considerably higher, than in the rats with intact tumour. This evidences for the corresponding increase of antioxidant protection of the organisms in the process of acquiring the tumour radioresistance.

[The cytological characteristics of a radioresistant variant of the L929 line]. / Tsitologicheskaia kharakteristika radiorezistentnogo varianta shtamma L929.

The dose-effect dependence in the dose interval 5-20 Gy the LD50 for L929 cell culture has been investigated. It is 11.8 Gy. After successive irradiation with 12 Gy LD50 of surviving cell has grown to 14 and 16 Gy. The acquisition of radioresistance is accompanied with the increase of cell polymorphism, quantity of intercellular contacts and multikaryon structure formation.

[Thiol group content in blood serum and in tumor tissue of rats with intact and radioresistant variants of Guerin carcinoma]. / Soderzhanie tiolovykh grupp v syvorotke krovi i v tkani opukholi krys s intaktnym i radiorezistentnym variantami kartsinomy gerena.

Interrelation between the formation of the secondary acquired radioresistance of Guerin carcinoma cells and dynamics of content of thiol groups in the tumour tissue and blood serum of rats have been studies. It is established that the tumour tissue and normal tissues (blood serum) of rats with Guerin's carcinoma respond to the fractional radiation action and to repeated courses of radiation therapy by the reactive increase of the number of free non-protein thiol groups and by the decrease of the content of protein thiols. The use of local superhigh-frequency-hypothermia in the pattern of treatment of the Guerin carcinoma strain resistant to irradiation is accompanied by the increase of the reaction capacity of non-protein thiol groups of the tumour tissue. At the same time the level of general thiol groups in the blood serum decreases while their reactivity increases.

[Radiation protective effect of low molecular weight thymus preparations]. / Protivoluchevoe deistvie nizkomolekuliarnykh preparatov vilochkovoi zhelezy.

The antiradiation efficiency of low molecular thymic preparations (vilosen, thymogen) was determined. The therapeutic activity of thymic preparations is due to their influence on basic radiation injury syndromes (hemopoietic, gastrointestinal, immunodepressive). The protective mechanisms and perspectives of thymic preparations using in pathogenic therapy of radiation diseases are discussed.

[Magnetic resonance tomography in the diagnosis and differentiation of cerebral stroke]. / Magnitno-rezonansnaia tomografiia v diagnostike i differentsiatsii mozgovykh insul'tov.

Assessment of the MRT with an ultra-low magnetic intensity (0.04 Tesla) in 112 patients with different brain strokes has demonstrated the method to be of high information content from the standpoint of the diagnosis and differentiation of foci of injury. MRT is of special importance for detection of lacunar and mixed infarction and foci of stem localization. The use of MRT in the course of the disease permits estimation of the physicochemical and biological processes that occur in ischemia and hemorrhage together with the quality of the treatment given to the patients.

[The intravital detection of spontaneously incorporated radionuclides in the human body]. / Prizhiznennoe vyiavlenie spontanno inkorporirovannykh radionuklidov v organizme cheloveka.

A trial has been done for the first time to use historadiography for detection of spontaneously incorporated radionuclides in the body of persons who participated in liquidation of the Chernobyl atomic station disaster. The effect of incorporated radiation on the gastric mucosa, blood and bone marrow was studied. 88% of patients showed different degrees of accumulation of radionuclides in mucosal epithelium and submucosal layer of the stomach.

[The clinical and instrumental characteristics of the sequelae of closed brain trauma]. / Klinicheskaia i instrumental'naia kharakteristika posledstvii zakrytoi travmy golovnogo mozga.

The complex analysis of clinico-instrumental data obtained during the examination of 220 patients with nonpenetrating cerebral trauma made it possible to determine the main neurologic syndromes and variants of clinical course of trauma consequences. The article shows the role of additional methods for objective studying of neurologic disorders, and for closer definition of cerebral pathology and pathogenetic mechanisms of some neurologic syndromes. The authors give a comparative characteristic of clinical, instrumental and psychological methods of study. The research has shown that there were no straight dependency between the gravity of trauma in the acute period and its possible consequences.

[The pathophysiological basis for the treatment of patients with a vertebrogenic pain syndrome localized in the lumbosacral region]. / Patofiziologicheskoe obosnovanie lecheniia bol'nykh s vertebrogennym bolevym sindromom poiasnichno-kresttsovoi lokalizatsii.

Experience of treatment of 84 patients with radicular syndrome of lumbo-sacral localization revealed the efficacy of multifactorial effect on different structures of the nervous system responsible for generation and realization of pain impulsation. Treatment was carried out with consideration of pathogenetic factors forming the pain syndrome, namely, compression of the root, functional blocks, spinal reactive aseptic epiduritis, arterial dyscirculation, disorders of venous outflow, psychogenic factors.

[Clinico-morphological characteristics of complex types of stroke]. / Kliniko-morfologicheskie osobennosti slozhnykh vidov insu'lta.

Mixed and associated forms of stroke are referred to as combined. These have their features of clinical course and pathomorphology. Selected issues of pathogenesis and therapy of these disorders are discussed. Combined strokes and their sub-items, mixed and associated, are worth including into existing "Classification of cerebral vascular diseases".

[Creatine phosphokinase in the cerebrospinal fluid of patients with stroke in the acute period]. / Kreatinfosfokinaza v spinnomozgovoi zhidkosti u bo'lnykh s insu'ltamiv ostrom periode.

Creatine phosphokinase (CP) activity was increased in the cerebrospinal fluid (CSF) in stroke patients as compared to a group of control patients. CP activity tended to be higher in hemorrhagic stroke as compared to ischemic one. The brain isoenzyme CP has a major impact on its total activity (above 75%). The presence of muscular CP isoenzyme in the CSF of stroke patients was explained by increased blood-brain barrier permeability, and blood admixture to SCF.

[Difficulties in the diagnosis of brain tumors]. / O zatrudneniiakh v diagnostike opukholei golovnogo mozga.

In 27 patients brain tumors were misdiagnosed for several years. Most mistakes were due to the incomplete analysis of the patients' complaints, anamnesis and peculiarities of the disease development. Most difficult were identifying the leading neurologic deficit, detecting the adjacent and remote signs. Using full sequence of both simple and sophisticated diagnostic techniques (PET, angiography, CT etc.) one can sharply reduce the incidence of diagnostic errors.

[Suppression of the proliferative activity in in vivo tissue culture of esophageal and stomach tumor cells during preoperative irradiation]. / Ugnetenie proliferativnoi aktivnosti v kul'ture tkani in vivo kletok opukholei pishchevoda i zheludka pri predoperatsionnom obluchenii.

Pathomorphological changes and indices of proliferative ability of tumour tissue in the esophagus and in the cardia are studied in 14 patients after and without the preoperative irradiation following its cultivation in diffuse chambers. The tissue was implanted into the abdominal cavity of 84 rats. Inhibition of the mitotic activity and synthesis of DNA in cell nuclei as well as the impairment of the formation processes typical of the unirradiated blastomas of the same histological structure in the tissue culture in vivo evidence for a pronounced effect of irradiation.

[Clinical picture and changes in the activity of several cerebrospinal fluid enzymes in stroke]. / Klinicheskaia kartina i izmeneniie aktivnosti nekotorykh fermentov spinnomozgovoi zhidkosti pri mozgovykh insul'takh.

Having studied the clinical picture and changes in the activity of various enzymes in the cerebrospinal fluid (CSF) in 140 patients with cerebral strokes, the authors showed a diagnostic and prognostic value of determining the activity of LDH and GGTP in the CSF. The activity of these enzymes increased in hemorrhagic stroke and in cases of unfavourable outcome. Their activity was lower in ischemic stroke and in cases of a favourable course of the disease.