Potential for femoral size optimization for off-the-shelf implants: A CT derived implant database analysis.

In total knee arthroplasty, the femoral implant size is chosen mainly based on the femoral anteroposterior (AP) height and mediolateral (ML) width. This choice often is a compromise, due to limited size availability. Inadequate AP fit is expected to alter flexion laxity and thus knee function. Inadequate ML fit entails underhang or overhang, which is linked to worse clinical outcomes. Hence, we aimed to find implant size distributions, which maximize population coverage, and to evaluate the sensitivity regarding error bounds and the number of implant sizes for a database of 85,143 cases. All patients in the database have been provided with a patient-specific implant in the past. For a subset of 1049 cases, three-dimensional preoperative bone surface models were available. These were used to validate whether the implant dimensions were representative of the bone dimensions. Particle Swarm Optimization was used for optimizing the implant size distribution. The deviations between implant and bone measures in the subset were found to be clinically irrelevant. Therefore, the full database of 85,143 cases was used for further analyses. A higher sensitivity of the population coverage regarding the error bounds compared to the number of implant sizes was found. For an exemplary setup of 12 optimized implant sizes and error bounds of ±1.5 mm for AP and ±3 mm for ML, a population coverage of almost 85% was achieved. In contrast, even with 30 implant sizes, a full population coverage could not be reached. Hence, remaining cases should be provided with patient-specific implants.

High variability of proximal tibial asymmetry and slope: a CT data analysis of 15,807 osteoarthritic knees before TKA.

PURPOSE: As the correct rotational and sagittal alignment of the tibial tray are of key importance for optimal total knee arthroplasty (TKA) function, the objective of this study was to determine these individual variations in the proximal tibial geometry in terms of posterior tibial slope (PTS) and tibial surface asymmetry by analysing a large dataset of computer tomography (CT) information. METHODS: A retrospective two-part review was performed on 15,807 datasets that were generated during the design phase for a customized TKA implant. First, 15807 CAD (computer-aided-design) models derived from CT data were used to conduct the analysis on the variation of the PTS. Second, the axial cut of each proximal tibia in a consecutively selected subset of 2202 datasets was used to measure the tibial asymmetry. RESULTS: The majority (65.5%) of tibiae had a posterior slope between 5° and 10°, while 26.5% of knees had a slope > 10°. The asymmetry measured as offset between the lateral and medial posterior boundaries was highly variable, with overall an increasing proportion of patients with high asymmetry with increasing tibial ML width. Only 14% of tibiae exhibited symmetric (< 2 mm offset) lateral and medial plateaus, and 22% had an offset > 5 mm. CONCLUSION: This study from an extraordinary large data base reveals that tibial posterior slope and asymmetry of the tibial profile vary largely between patients receiving TKA with increasing tibial asymmetry with ML width. CT scans might help to preoperatively better select the best fitting TKA, otherwise surgeons intraoperatively will often have to deal with compromises regarding fitting, sizing and rotational issues. LEVEL OF EVIDENCE: Retrospective case series, Level IV.

What Is the Possible Impact of High Variability of Distal Femoral Geometry on TKA? A CT Data Analysis of 24,042 Knees.

BACKGROUND: Previous studies analyzing femoral components of TKAs have demonstrated the limited ability of these components to accommodate size variations seen in the patient population, particularly width and femoral offset. QUESTIONS/PURPOSES: The purpose of this study was to use a large data set of knee CT scans (1) to determine the variations in the distal and posterior femoral geometries and to determine whether there is a correlation between distal condylar offset and posterior femoral offset as a potential parameter for symmetry/asymmetry; and (2) to evaluate what proportion of knees would have a substantial mismatch between the implant's size or shape and the patient's anatomy if a femoral component of a modern standard TKA of symmetric (sTKA) or asymmetric (asTKA) designs were to be used. METHODS: A retrospective study was performed on 24,042 data sets that were generated during the design phase for a customized TKA implant. This data set was drawn from European and US-American patients. Measurements recorded for the femur included the overall AP and mediolateral (ML) widths, widths of the lateral condyle and the medial condyle, the distal condylar offset (DCO) between the lateral and medial condyles in the superoinferior direction, and the posterior femoral offset (PFO) as the difference between the medial and lateral posterior condylar offset (PCO) measured in the AP direction. A consecutively collected subset of 2367 data sets was further evaluated to determine the difference between the individual AP and ML dimensions of the femur with that of modern TKA designs using two commercially available implants from different vendors. RESULTS: We observed a high degree of variability in AP and ML widths as well as in DCO and PFO. Also, we found no correlation between DCO and PCO of the knees studied. Instances of a patient having a small DCO and higher PCO were commonly seen. Analysis of the DFOs revealed that overall, 62% (14,906 of 24,042) of knees exhibited DCO > 1 mm and 83% (19,955 of 24,042) of femurs exhibited a > 2-mm difference between the lateral and medial PCO. Concerning AP and ML measurements, 23% (544 of 2367) and 25% (592 of 2367) would have a mismatch between the patient's bony anatomy and the dimensions of the femoral component of ± 3 mm if they would have undergone a modern standard sTKA or asTKA design, respectively. CONCLUSIONS: Analysis of a large number of CT scans of the knee showed that a high degree of variability exists in AP and ML widths as well as in DCO and PFO. CLINICAL RELEVANCE: These findings suggest that it is possible that a greater degree of customization could result in surgeons performing fewer soft tissue releases and medial resections than now are being done to fit a fixed-geometry implant into a highly variable patient population. However, as an imaging study, it cannot support one approach to TKA over another; comparative studies that assess patient-reported outcomes and survivorship will be needed to help surgeons decide among sTKA, asTKA, and customized TKA.

In Vivo Three-Dimensional Patellar Mechanics: Normal Knees Compared with Domed and Anatomic Patellar Components.

BACKGROUND: Patellofemoral complications are a major cause of revision surgery following total knee arthroplasty (TKA). High forces occurring at the patellofemoral articulation coupled with a small patellofemoral contact area pose substantial design challenges. In this study, the three-dimensional (3D) in vivo mechanics of domed and anatomically shaped patellar components were compared with those of native patellae. METHODS: Ten normal knees, 10 treated with an LCS-PS (low contact stress-posterior stabilized) TKA (anatomically shaped patellar component), and 10 treated with a PFC Sigma RP-PS (press-fit condylar Sigma rotating platform-posterior stabilized) TKA (domed patellar component) were analyzed under fluoroscopic surveillance while the patient performed a weight-bearing deep knee bend from full knee extension to maximum knee flexion. Relevant bone geometries were segmented out from computed tomography (CT) scans, and computer-assisted-design (CAD) models of the implanted components were obtained from the manufacturer. Three-dimensional patellofemoral kinematics were obtained using a 3D-to-2D registration process. Contact mechanics were calculated using a distance map between the articulating patellar and femoral surfaces. RESULTS: Both patellar component designs exhibited good rotational kinematics and tracked well within the femoral trochlea when compared with the normal patella. The contact areas in the TKA groups peaked at 60° of knee flexion (mean and standard deviation, 201 ± 63.4 mm for the LCS-PS group and 218 ± 95.4 mm for the Sigma RP-PS group), and the areas were substantially smaller than those previously reported for the normal patella. Contact points in the TKA groups stayed close to the center of the patellar components. CONCLUSIONS: Both designs performed satisfactorily, although patellofemoral contact areas were reduced in comparison with those in the native patella. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

In vivo kinematic effects of ball and socket third condyle as a post-cam mechanism in tri-condylar knee implants.

BACKGROUND: Tri-condylar implants containing a ball and socket third condyle as a post-cam mechanism were developed to accommodate a lifestyle requiring frequent deep flexion activities. The purpose of the current study was to examine the kinematic effects of the ball and socket third condyle during a deep knee bend activity, and to confirm the contact status of the ball and socket joint. METHODS: Seventeen knees implanted with tri-condylar implants were analyzed using a 3D to 2D registration approach. A distance of less than 1mm denoted ball and socket contact. Medial and lateral contact positions and axial rotation were compared before and after contact. Moreover, the contact position at the third condyle and the center of the ball joint were analyzed. RESULTS: After the third condyle contact, posterior translation of the medial and lateral contact positions increased considerably. Meanwhile, the angular rotation remained still. The center of the third condyle did not move after contact, and the contact position at the third condyle remained low. CONCLUSIONS: The third condyle induced intensive posterior translation of both condyles, and did not prevent axial rotation, which was proved to work properly as a posterior stabilizing post-cam mechanism.

Kinematic difference between various geometric centers and contact points for tri-condylar bi-surface knee system.

The purpose of the study was to analyze the motion of contact points (CPs), lowest points (LPs), and component facet centers of tri-condylar implants. In vivo knee kinematics was assessed for 43 knees implanted with a multi-radii femoral component during deep knee bend activity, using a model fitting approach. Both LPs had the similar positions to the corresponding geometric centers of the femoral component, and the LP and geometric center angles represented the same component rotation angle defined by Grood and Suntay. Antero-posterior translation of both CPs was significantly overestimated, compared to LPs, and the CP angle showed significant differences from other rotation angles. In conclusion LPs seemed better to evaluate kinematics than CPs because polyethylene congruity had considerable effects on CP analysis.

Can post-cam function be replaced by addition of a third condyle in PS TKA?

The purpose of the study was to analyze the effectiveness of an additional ball and socket articulation in implanted knees and whether it can replicate post-cam function. Fifteen knees implanted with a cruciate substituting (CS) polyethylene without a post and ten knees implanted with a posterior stabilized (PS) polyethylene with a post were analyzed using 3D model fitting approach. Two types of designs showed similar posterior translation and similar axial rotation. Most of the contact points at the ball and socket joint stayed within the socket height for the PS group. This study indicates that the ball and socket joint is able to function as a replacement of the post-cam mechanism, which might serve as a new way to achieve posterior stability.

In vivo determination of cam-post engagement in fixed and mobile-bearing TKA.

BACKGROUND: Kinematics vary, sometimes in important ways, among the different types of total knee arthroplasty (TKA) designs, yet differences between the in vivo mechanisms of cam-post engagement in rotating-platform posterior-stabilized (PS) TKA, bicruciate-stabilized TKA, and fixed-bearing PS TKA designs remain largely uncharacterized. QUESTIONS/PURPOSES: The objective of this study was to determine the cam-post mechanism interaction for subjects implanted with three different TKA designs. METHODS: In vivo, analysis was conducted for patients implanted with nine rotating-platform PS TKAs, five knees with a fixed-bearing PS TKA, and 10 knees with a bicruciate-stabilized TKA while performing a deep knee bend. Three-dimensional kinematics of the implant components were determined by analysis of fluoroscopic images during flexion. The distances between the interacting surfaces were measured throughout flexion and instances and locations of contact were identified. RESULTS: Seven of the 10 bicruciate-stabilized knees analyzed had the femoral component engaged with the anterior aspect of the tibial post at full extension. Posterior cam-post engagement occurred at 34° for the bicruciate-stabilized (range, 17°-68°), 93° for the fixed-bearing PS (range, 88°-100°), and at 97° (range, 90°-104°) for rotating-platform PS TKA. In bicruciate-stabilized and fixed-bearing PS knees, the contact initially occurred on the medial aspect of the posterior surface of the tibial post and then moved centrally and superiorly with increasing flexion. For rotating-platform PS TKA, it was located centrally on the posterior surface of the post at all times. CONCLUSIONS: This study suggests that mobility of the polyethylene might play an important role in ensuring central cam-post interaction in PS TKA. The polyethylene insert rotates axially in accordance with the rotating femur, maintaining central cam-post contact. This phenomenon was not observed in the fixed-bearing PS TKAs analyzed in this study. CLINICAL RELEVANCE: We speculate that this centralized symmetrical contact between the cam and posterior surface of the post could be beneficial clinically in terms of reducing wear of the posterior surface and particularly at the medial extremes of it.

3D in vivo femoro-tibial kinematics of tri-condylar total knee arthroplasty during kneeling activities.

BACKGROUND: Kneeling position can serve as an important posture, providing stability and balance from a standing position to sitting on the floor or vice-versa. The purpose of the current study was to determine the kinematics during kneeling activities after subjects were implanted with a tri-condylar total knee arthroplasty. MATERIALS AND METHODS: Kinematics was evaluated in 54 knees using fluoroscopy and a three-dimensional model fitting approach. RESULTS: The average knee flexion at before contact status, at complete contact and at maximum flexion was 98.1±9.0°, 107.2±6.7°, and 139.6±12.3°, respectively. On average, there was no gross anterior displacement from before contact status to complete contact. Only slight posterior rollback motion of both condyles from complete contact to maximum flexion was observed. Three of 39 (7.7%) knees experienced anterior movement of both condyles more than 2mm from before contact status to complete contact. Reverse rotation pattern from before contact status to complete contact and then normal rotation pattern from complete contact to maximum flexion were observed. Condylar lift-off greater than 1.0 mm was observed in 45 knees (83.3%). CONCLUSION: The presence of the ball-and-socket joint articulation provides sufficient antero-posterior stability in these designs to enable the patients to kneel safely without the incidence of any dislocation. CLINICAL RELEVANCE: This study suggests a safe implant design for kneeling.

Femoral condylar contact points start and remain posterior in high flexing patients.

This study compares kinematic patterns of 136 patients following total knee arthroplasty with high post-operative knee flexion (HighFlex) versus kinematics of 114 patients with limited knee flexion (LowFlex) using a blocked stratified random sampling study design to reduce confounding and bias. The kinematics was collected using fluoroscopy and 2D to 3D registration for a weight-bearing deep knee bend activity. Both the lateral and the medial condylar contact positions for the HighFlex subjects were significantly more posterior than the LowFlex subjects at full extension and remained that way at all flexion angles. The amount translation of the contact points, axial orientation angle and axial rotation were found to be similar for the two groups. Lift-off was significantly higher in the LowFlex indicating mid-flexion instability.

Lack of axial rotation in mobile-bearing knee designs.

It has often been assumed rotational kinematics are improved with mobile-bearing TKA designs as the terms mobile-bearing and rotating platform imply. We tested this assumption by assessing the in vivo axial rotation magnitudes and patterns of 527 knees implanted with 12 different mobile-bearing TKA designs. Implants were grouped and compared by type--posterior stabilized (PS), posterior cruciate retaining (PCR), and posterior cruciate sacrificing (PCS)--and by specific design. We hypothesized all three mobile-bearing types (PS, PCR, and PCS) would achieve greater than 10 degrees average axial rotation and we would find no differences in axial rotation between types. Only 14% of PS knees, 3% of PCS knees, and 17% of PCR knees attained greater than 10 degrees axial rotation when measured from 0 degrees to 90 degrees . The percentage of PCS knees with greater than 10 degrees axial rotation was less compared with the other two groups. Axial rotation averaged 4.3 degrees , 2.5 degrees , and 3.8 degrees for the PS, PCS, and PCR knees, respectively. Incidences of reverse rotation were observed in 17% of PS knees, 32% of PCS knees, and 28% of PCR knees. Compared with the PCS group, the PS group achieved greater average axial rotation and had a lower percentage of knees displaying incidences of reverse rotation. The data refuted the hypotheses.

Factors affecting flexion after total knee arthroplasty.

UNLABELLED: Results of total knee arthroplasty have demonstrated excellent pain relief and increased patient function, particularly in activities such as walking. This procedure has not always met the needs of certain ethnic and religious groups as well as younger patients who require greater magnitudes of knee flexion. This has resulted in the introduction of new implant designs engineered to improve postoperative flexion. We reviewed factors known to influence postoperative flexion after total knee arthroplasty. An in vivo, weightbearing fluoroscopic kinematic analysis of multiple high-flexion total knee arthroplasty designs was performed, and demonstrated high levels of weightbearing flexion (125 degrees) can be obtained in some, but not all, evaluated designs. Multiple evaluations of the same high-flexion total knee arthroplasty design performed by different surgeons and involving different patient populations revealed one study group with high weightbearing flexion and other groups that did not achieve high flexion. This suggests numerous factors other than implant design influence eventual flexion, including the patient, surgical technique, knee kinematics, perioperative complications, and postoperative physiotherapy. LEVEL OF EVIDENCE: Level V, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.