ABSTRACT
The subject of investigation was the comparison of HLA antigen distribution in people with borderline hypertension (BH) and essential hypertension (EH). One hundred twenty-one men with BH and 60 men with EH were studied. The HLA frequency was compared with that in 858 healthy men, who were blood donors. In BH the increase of B16, B18, and Cw4 and the decrease of A11 and B5 antigen frequency were found. In comparison with St. Petersburg's healthy population, patients with EH were characterized by increasing antigens B18, B41, Cw2, and Cw4 frequency. The coincidence of increased antigen B18 and Cw4 representation in BH and EH allows us to consider them to be immunogenetic markers or predictors of development of EH.
Subject(s)
Histocompatibility Antigens Class I/analysis , Hypertension/immunology , Adolescent , Adult , Humans , MaleABSTRACT
The authors analyze the frequency of HLA [correction of HIA] antigens in 121 male patients with borderline arterial hypertension and in 60 patients with hypertensive disease, stage II. The frequency of HLA [correction of HIA] antigens in these patients was compared with their frequency in the male population of Leningrad inhabitants (858 healthy donors). Patients with borderline arterial hypertension showed a characteristic increase of the frequency of B16, B18 CW4 antigens. The presence of an increase representation of B18 and C4 antigens in both groups makes it possible to consider them as immunogenetic markers of the development of arterial hypertension.
Subject(s)
HLA Antigens/blood , Hypertension/immunology , Adolescent , Adult , Chi-Square Distribution , Humans , Hypertension/epidemiology , Hypertension/etiology , Male , Middle Aged , PhenotypeSubject(s)
HLA Antigens/genetics , Hypertension/etiology , Adolescent , Adult , Disease Susceptibility , HLA Antigens/analysis , HLA-A Antigens/analysis , HLA-A Antigens/genetics , HLA-B Antigens/analysis , HLA-B Antigens/genetics , HLA-C Antigens/analysis , HLA-C Antigens/genetics , Humans , Hypertension/epidemiology , Hypertension/genetics , Male , Russia/epidemiology , Sex FactorsABSTRACT
The spectrum of HLA antigens was studied in 619 control subjects and 357 patients with atherosclerosis of various localization (coronary, cerebral, and lower limbs arteries). Comparative analysis has shown both agreement and differences to exist between patient groups depending on atherosclerosis localization. Significant differences were also found in the level of various lipid components. A relationship between HLA antigens and lipid markers was demonstrated, especially between locus B and C antigens and HDL cholesterol level. The authors believe the findings can be utilized to determine predisposition to atherosclerosis of various localization.