[The results of the adjuvant chemotherapy of patients with small-cell lung cancer]. / Rezul'taty ad''iuvantnoi khimioterapii bol'nykh melkokletochnym rakom legkogo.

The effectiveness of treatment (surgery; surgery + chemotherapy) was compared in a group of 122 patients with small-cell lung cancer. Median survival after postoperative chemotherapy rose from 40.9 to 81.8 weeks. However, five-year survival was nearly identical--8.1% (surgery) and 10.0% (surgery + chemotherapy).

[In vitro determination of the sensitivity of lung tumors to different drugs]. / Opredelenie in vitro chuvstvitel'nosti opukholei legkikh k razlichnym lekarstvennym preparatam.

The in vitro sensitivity of 193 lung tumour specimens to anticancer agents was investigated using the short-term culture method. It is shown that there are many anticancer drugs with correlative effectiveness. It often concerns preparations with different mechanism of action. Using the in vitro sensitivity test data of correlative effectiveness it is possible not only to investigate the activity of new synthesized compounds and well known preparations but also to draw poly-chemotherapy schemes with these agents in relatively short time.

[In vitro sensitivity of epidermoid lung cancer to cytostatics depending upon the degree of tumor differentiation]. / Chuvstvitel'nost' épidermoidnogo raka legkikh in vitro k tsitostatikam v zavisimosti ot stepeni differentsiatsii opukholi.

In vitro sensitivity of epidermoid lung carcinoma to chemotherapeutic agents in short-term cultures versus degree of tumor differentiation was evaluated for the following drugs: 5-fluorouracil, methotrexate, olivomycin, bleomycin, carminomycin, adriablastin, prospidium chloride, vincristine, thiophosphamide, novembichine and photrine. The results of the investigation using resected material from 77 cases of histologically confirmed epidermoid lung carcinoma failed to establish any relationship between the parameters under study for all above drugs except vincristine. However, tumors showing similar levels of differentiation demonstrated different sensitivity to certain drugs.

[Determination of the effectiveness of antiblastic chemotherapy by morphologic signs of tumor cell damage]. / Opredelenie éffektivnosti antiblasticheskoi khimioterapii po morfologicheskim priznakam povrezhdeniia opukholevykh kletok

All known morphological signs of cell dystrophy are systematized. Each cell was described according to multiple morphological signs (100 cells in each specimen); 20 000 tumor cells in carcinomatous exudates of patients with different localizations of malignant tumor were studied during the course of treatment, and 9 100 cells of experimental Brown-Pearce tumors were subjected to various effects. There were revealed more informative signs for judging the efficacy of treatment in patients. Based on more informative signs, which proved to be nucleoli signs, the indices for nucleoli were elaborated to determine the degree of tumor cells injury and to estimate the efficacy of treatment of patients by means of alkylating antiblastic substances. A semiautomatic set "Cytoclassificator" was employed for the study.