ABSTRACT
Two hundred ten patients with endometrial and cervical carcinoma had para-aortic node biopsies. Nineteen of the 210 patients (9.0%) had positive para-aortic nodes. These 19 patients received pelvic irradiation, and 18 patients received para-aortic irradiation. The incidence of para-aortic nodal involvement in cervical carcinoma was directly related to the stage of the disease. Eleven of the 12 patients with cervical carcinoma and positive para-aortic nodes received both pelvic and para-aortic irradiation. Three of these patients are alive without disease, resulting in a survival rate of 25%. These patients are surviving for 16, 30, and 41 months. The incidence of positive para-aortic nodes in endometrial adenocarcinoma was related to the uterine length and the histologic grade. The survival rate for patients with endometrial adenocarcinoma and positive para-aortic nodes in this study was 57.1%. Four patients have survived for 1, 30, 60, and 71 months. There were no surgical deaths or radiation therapy complications directly attributable to para-aortic biopsy or irradiation.
Subject(s)
Adenocarcinoma/pathology , Carcinoma/pathology , Lymph Nodes/pathology , Uterine Cervical Neoplasms/pathology , Uterine Neoplasms/pathology , Adenocarcinoma/mortality , Adenocarcinoma/radiotherapy , Adenocarcinoma/surgery , Aorta , Biopsy , Carcinoma/mortality , Carcinoma/radiotherapy , Carcinoma/surgery , Female , Humans , Lymphatic Metastasis , Prognosis , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/radiotherapy , Uterine Cervical Neoplasms/surgery , Uterine Neoplasms/mortality , Uterine Neoplasms/radiotherapy , Uterine Neoplasms/surgeryABSTRACT
Retrospective review of 118 primarily treated cancers of the oral tongue was done to study patient selection and to search for improved treatment strategies. Small surface lesions were treated by local excision (LE); most small lesions invading muscle of the tongue without lymph node metastases were treated by radiation alone (RA) while larger lesions and those with palpable nodes were treated by preoperative radiation and surgery (R + S). Ultimate control of the primary tumor and lymph nodes after initial treatment and surgical salvage was high for the lesions by LE (91%), the T1N0 lesions treated by RA (88%) and for the TxN+ lesions treated by R + S (57%). Improved treatment strategies are suggested for T2N0 lesions treated by RA because of poor tumor control (53%) and a high rate of radiation complications (25%), and for T3N0 lesions because so many of these patients died from causes other than cancer within two years. Second primary cancers were most common in those patients with a good prognosis.
Subject(s)
Tongue Neoplasms/therapy , Aged , Brachytherapy/adverse effects , Female , Head and Neck Neoplasms/secondary , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Staging , Neoplasms, Multiple Primary , Radiation Injuries/etiology , Retrospective Studies , Tongue Neoplasms/mortality , Tongue Neoplasms/radiotherapy , Tongue Neoplasms/surgeryABSTRACT
Metastatic malignant thymoma developed in a 64-year-old man after a 9-year history of myasthenia gravis. Following good response to irradiation of the mediastinal mass and osseous metastasis, pure red cell aplasia developed.
