Subject(s)
Skin Physiological Phenomena , Biomechanical Phenomena , Biophysics/instrumentation , Elasticity , Humans , Methods , Microcomputers , ViscosityABSTRACT
Free fatty acids in the serum of 60 patients with generalized psoriasis were studied by a gas-chromatographic method. The same investigations in 40 healthy persons served for control purposes. It was established with statistical probability (p less than 0.001) that in the serum of psoriatics the levels of palmitic (C 16: 0), stearic (C 18: 0), arachidic (C 20: 0), and docosadienic (C 20: 2) acids were increased, while the levels of the linoleic (C 18: 2) and arachidonic (C 20: 4) acids were depressed. There is no behenic acid (C 22: 0) in the blood serum of psoriatics. Thalassotherapy caused no significant changes in the levels of these free fatty acids in psoriatics.
Subject(s)
Fatty Acids, Nonesterified/blood , Psoriasis/blood , Adult , Climatotherapy , Female , Humans , Male , Middle Aged , Psoriasis/therapyABSTRACT
The anti-DNA antibody titer (heat denatured, native and monostranded) was studied in 61 patients with psoriasis and 41 healthy controls. Positive titers of anti-DNA antibodies were established in 19.3% of the psoriatics and in 4.9% of the controls. Antibodies against heat-denatured DNA were discovered in 8.2% of the patients and in 0% of the healthy persons; against native DNA in 18% of the psoriatics and 4.9% of the controls and against monostranded DNA in 31.7% of the psoriasis patients and 9.8% of the control group. In general, the percentage of the positive titers of anti-DNA antibodies in psoriatics was about 4 times higher than that of the healthy controls.
Subject(s)
Antibodies, Antinuclear/analysis , DNA, Single-Stranded/immunology , DNA/immunology , Psoriasis/immunology , Adult , Climatotherapy , Female , Humans , Male , Middle Aged , Psoriasis/therapySubject(s)
HLA Antigens/analysis , Leukocytes/immunology , Psoriasis/immunology , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
In 192 patients with psoriasis an increased frequency of the antigens HLA-B13 (19.79%, X2 = 32.79, p less than 0.001), HLA-B17 (24.47%, X2 = 64,84, p less than 0.001), and HLA-B27 (19.27%, X2 = 11.07, p less than 0.001) in comparison with the control group of 1,085 clinically healthy persons, was established. After 4 weeks of thalassotherapy 3 groups of patients could be distinguished: (1) those with full clinical remission - 50 (26.8%), (2) those with great or moderate improvement - 116 (60.4%), and (3) those with no improvement - 26 patients (13.6%). In the first two groups there is a statistically significant association with the HLA antigens B13 and B17. In the third group (no improvement) there is no such association with HLA-B13 (p less than 0.01). Consequently, patients in whom psoriasis is associated with HLA-B13 were better influenced by the thalassotherapy. The variability in the therapeutic efficiency means that perhaps there is a genetic heterogenicity in the group of common psoriasis.
