[The combined treatment of patients with digestive tract diseases by the action of the enterosorbent Enterosgel and of the intravascular laser irradiation of the blood]. / Kompleksnoe lechenie bol'nykh s zabolevaniiami pishchevaritel'nogo kanala vozdeistviem énterosorbenta Enterosgel' i vnutrisosudistogo lazernogo oblucheniia krovi.

Rehabilitative, medical treatment involved a combined use of enterosorption (the drug Enterosgel) and intravascular laser irradiation of blood (ILIB). The results obtained showed the adopted combined mode of treatment (Enterosgel + ILIB) to have a positive effect on the patients' body. The above alternative while eliminating the remainder from the body promotes an increase in the content of large granule-containing lymphocytes, which events result in restoration of those morphology of those leucocytes having undergone degeneration, with crystallization of saliva getting back to normal. Considering the present health-hazard conditions, negative environmental effects on human organism, the above treatment option is indicated not only to patients having disorders of the alimentary canal but also to those presenting with other pathologies, as well as for preventive and health-promoting purposes.

[The natural resistance of the inhabitants of Kiev 10 years after the accident at the Chernobyl Atomic Electric Power Station]. / Sostoianie estestvennoi rezistentnosti zhitelei Kieva spustia desiat' let posle avarii na ChAES.

A study was made of the natural resistance status in inhabitants of Kiev over ten years after the Chernobyl power plant accident. The results obtained showed that small doses of ionizing radiation exert a negative effect on the body inducing morphological changes in leucocytes, lowering the blood absolute content of large granule-containing lymphocytes, causing decline in the level of natural killer activity, changes in leucocyte as well as lymphocyte counts. In inhabitants of Kiev, post-Chernobyl changes in the studied parameters-tend to get more pronounced with time.

[The effect of natural immunomodulators on the lymphocytic natural killer activity in patients with malignant lymphoproliferative diseases]. / Vliianie prirodnykh immunomoduliatorov na estestvennuiu killernuiu aktivnost' limfotsitov bol'nykh zlokachestvennymi limfoproliferativnymi zabolevaniiami.

The conducted investigations showed an apparent immunomodulating action of the studied natural preparations on natural resistance of patients with malignant lymphomas. The modulation effect was the greatest in patients taking esberitox during remission and while receiving radiotherapy. Administration of Ney Tumorin to patients with lymphogranulomatosis during remission appeared to be associated with substantial increase in the content of large granular lymphocytes and level of natural killer activity (almost two--fold) immediately after the end of the treatment and this tendency was to be still seen one--two months later. Pirogenal had marked stimulatory effect on natural resistance of patients with granulomatosis in the postradiation period. The studied preparations were not associated with side effects. General condition improved after their administration, as per subjective experience.

[The natural body resistance of the inhabitants of the city of Kiev subsequent to the accident at the Chernobyl Atomic Electric Power Station]. / Estestvennaia rezistentnost' organizma zhiteli g. Kieva vsledstvie avarii na Chernobyl'skoi AES.

A study carried out among residents of the city of Kiev indicates that combined chronic radiation after the Chernobyl accident in small doses resulted in a reduction of the natural killer activity level, decrease of the number of leucocytes, lymphocytes and in their qualitative disorders. With time after the Chernobyl accident there occurred a deterioration of the above values.

[The treatment of patients with cancer of the corpus uteri using the gamma emitter 137Cs]. / Lechenie bol'nykh rakom tela matki s ispol'zovaniem gamma-izluchatelia 137Cs.

A study is presented of 51 patients (age 52-77 years) suffering of uterine body cancer with marked extragenital pathology. It is shown that treatment of inoperable cancer of the uterine body using the SELECTRON apparatus for contact irradiation (cesium-137 source, 066-MEV photons). With this method exact dose control is possible. The preferred regime of dose fractionation in intracavitary radiation of endometrium cancer is a single dose of 1000 cGr weekly and a summary dose of 7000-8000 cGr.

[The cytogenetic and clinico-hematological indices of the people subjected to mixed irradiation in the accident at the Chernobyl Atomic Electric Power Station]. / Tsitogeneticheskie i kliniko-gematologicheskie pokazateli u lits, podvergavshikhsia smeshannomu oblucheniiu pri avarii na Chernobyl'skoi AES.

It was established that adequate treatment during latent period of acute radiation sickness reduces to a significant degree the level of genetic changes in the lymphocytes of the peripheral blood of the victims. After treatment the signs and symptoms of the disease were less manifested.

[Changes in cytotoxicity of natural killer cells and level of large granule-containing lymphocytes in patients with lung cancer under the effects of cryosurgery]. / Izmenenie tsitotoksichnosti estestvennykh killerov i urovnia bol'shikh granulosoderzhashchikh limfotsitov u bol'nykh rakom legkogo pod vliianiem kriokhirurgii.

The parallel study of the content of large granule-containing lymphocytes (LGL) and natural killer activity (NKA) in donors, patients with benign tumors in the lungs and bronchial or pulmonary cancer in operative intervention and combined cryosurgical treatment was carried out. The stimulating effect of cryodestruction of malignant tumors with their subsequent spontaneous thawing on LGL content and NKA in patients was established. Administration of prodigiosan immunomodulator contributed to increase in natural resistance of an organism of the patients. The positive correlation of NKA and LGL content was noted.

[The count of the large granule-containing lymphocytes of the peripheral blood and the natural killer activity in patients with malignant tumors]. / Kolichestvo bol'shikh granulosoderzhashchikh limfotsitov perifericheskoi krovi i estestvennaia killernaia aktivnost' u bol'nykh zlokachestvennymi opukholiami.

The authors investigated the quantity of large granule-containing lymphocytes and natural killer activity in donors, in patients with malignant and benign diseases of the lungs, mammary gland and digestive tract at admission to the hospital; 234 examinations were carried out. Results of the investigation revealed an inhibition of the natural resistance in patients with diseases of the mammary gland, lungs, digestive tract. A positive correlation has been revealed between the natural killer activity and content of large granule-containing lymphocytes in donors and in patients at admission.

[The natural killer cell activity and count of large granule-containing lymphocytes in the blood of patients with malignant lymphomas]. / Aktivnost' estestvennykh killernykh kletok i kolichestva bol'shikh granulosoderzhashchikh limfotsitov v krovi bol'nykh zlokachestvennymi limfomami.

The authors investigated the natural killer activity and number of large granule-containing lymphocytes (LGL) in donors, in the blood of patients with reactive lymphadenitis, lymphogranulomatosis and non-Hodgkin lymphomas. Patients with lymphomas and lymphogranulomatosis were subdivided in groups depending on the morphological variant and stage of the disease, length of remission. Results of the study allowed to establish disorders of the natural antitumour resistance in patients with malignant lymphomas, its dependence on histological verification, stage of the process, morphological variant. A positive correlation was obtained between natural killer activity and content of LGL in donors and in patients with malignant lymphomas during first admission, prolonged stable remission and recurrences.

[The effect of combination cryosurgical treatment on the natural resistance of patients with cancer of the lung]. / Vliianie kombinirovannogo kriokhirurgicheskogo lecheniia na estestvennuiu rezistentnost' organizma bol'nykh rakom legkogo.

By the method of measuring the percentage and absolute content of the large granule-containing lymphocytes in the peripheral blood of the healthy subjects, in pulmonary cancer and benign process in the lungs at admission, just before the operation, at day 1 and at days 13-14 after the operative intervention and combined cryosurgical treatment, the data about the stimulating effect of cryodestruction on the natural resistance of an organism of the patients were obtained.

[Possibilities of preclinical and differential diagnosis of malignant neoformations according to the percentage of large granular lymphocytes]. / Vozhmosnosti doklinicheskoi i differentsial'noi diagnostiki zlokachestvennykh novoobrazovanii po soderzhaniiu bol'shikh granulosoderzhashchikh limfotsitov.

The paper discusses the results of application of a simple and easily available method of measuring levels of large granule-containing lymphocytes for identification of risk for cancer during mass screenings and differential diagnosis of benign and malignant tumor before morphological examination.

[Prospects for using the cryogenic factor in the radiation therapy of tumors]. / Perspektivy ispol'zovaniia kriogennogo faktora pri luchevoi terapii opukholei.

Experimental studies with 640 mongrel male rats with transplants of Guerin carcinoma and DMBA-induced tumours were performed. Separate groups of animals were subjected to isolated effects of cryodestruction, radiation therapy with total doses of 60 or 30 Gy and combined cryoradiation treatment by different schedule. The study revealed that an enhanced efficiency of combined treatment is achieved essentially by a two-fold decrease in the total irradiation dose in combination with tumour focal cryodestruction.