1.
Pediatr Pol
; 70(11): 915-20, 1995 Nov.
Article
in Polish
| MEDLINE
| ID: mdl-8677156
ABSTRACT
Urinary excretion of the markers of tubular nephrotoxicity, total NAG and isoenzymes A and B and B-2-M, were evaluated in urine of 21 children with acute lymphoblastic leukaemia after the first injection of cytostatic administrated according to the BFM scheme: VCR + Rub, L-aspa, CY, Ara-C. Every administrated drug caused temporary elevation in urinary excretion of total NAG and isoenzyme B and B-2-M. GFR was unchanged. These results point to nephrotoxicity of cytostatics. Peak total NAG, isoenzyme B and B-2-M excretion was observed on the third day after L-aspa and Ara-C injection.
Subject(s)
Acetylglucosaminidase/urine , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Isoenzymes/urine , Kidney Tubules/drug effects , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Asparaginase/administration & dosage , Biomarkers/analysis , Child , Cyclophosphamide/administration & dosage , Cytarabine/administration & dosage , Daunorubicin/administration & dosage , Humans , Vincristine/administration & dosage
2.
Wiad Lek
; 46(5-6): 224-5, 1993 Mar.
Article
in Polish
| MEDLINE
| ID: mdl-8249404