[Treatment of Cushing's syndrome with large doses of reserpine]. / Lechenie bolezni Itsenko-Kushinga bol'shimi dozami rezerpina.

The effectiveness of high doses of reserpine was studied in two groups of patients, suffering from Icenko-Cushing's disease. The patients of the first group received gamma-beam therapy combined with high doses of reserpine. The patients of the second group were treated with gamma-beam radiation associated with unilateral adrenalectomy plus high doses of reserpine. The controls were treated as described above, but without reserpine use. The results obtained have shown that reserpine monotherapy is not recommended in Icenko-Cushing's disease. High doses of reserpine combined with gamma-beam radiation alone or coupled with unilateral adrenalectomy shortened the period of the appearance of remission. The arterial blood pressure was significantly lower in patients treated with high doses of reserpine.

[Diagnostic and surgical tactics in primary hyperparathyroidism]. / Vuprosi na diagnostikata i operativnata taktika pri purvichniia khiperparatireoidizum.

Fifty seven patients with primary hyperparathyroidism are reported to be successfully operated. The pneumomodiastinography and hypotensive esophagoscopy, according to Reimberg--Semzov, were used for preoperation localization of the pathologically changed para thyroid glands. Operation technique applied in adenoma, hyperplasia and carcinoma of parathyroid glands is described. The lethality of the operations performed is 0 per cent. The early and late postoperative results are analyzed as well as the favourable effect on the alterations in the osseous, gastrointestinal and excretory system. The necessity of early diagnosis of the disease is stressed upon as well as the timely performance of the operation.

[Chronic recurrent pancreatitis with erosive gastritis in a patient with primary hyperparathyroidism]. / Khronichen retsidivirasht pankreatit s eroziven gastrit pri bolna s purvichen khiperparatireoidizum

A female with premary hyperparathyroidism and secondary renal lesions, as well as lesions of the stomach and pancreas is described. The initial illness was manifested by repeated renal crises. Later, gastroenterological complaints appeared--epigastralgia, vomiting, frequent hematemesis with melena. That was the cause for a gastric resection, diffuse erosive gastritis being found. After the operation, the pains and the vomiting of hematin matter repeatedly recidivated. Clinically and at the laboratory, data were formed for a chronic recidivating pancreatitis with the presence of primary hyperparathyroidism. The postoperative treatment of the parathyroid adenoma led to an improvement of the gastroenterological complaints.