ABSTRACT
Atopic dermatitis (A.D.) is a hereditary and distinct form of eczema which may be associated with other atopic manifestations. The aetiopothogenesis of A.D. is unknown and it is widely accepted that both intrinsic and extrinsic factors are involved. House dust mites (HDM) are of great medical importance in causing allergic manifestations in human being. In the present work, a total of 30 A.D. patients with different ages of both sexes were examined for the immunoglobulins level as compared to control group. The IgG, IgM, IgA & IgE were higher in the patients than in the controls. These differences were highly significant in the IgE. On the other hand, IgA showed no significant increase.
Subject(s)
Dermatitis, Atopic/immunology , Immunoglobulins/blood , Mite Infestations/complications , Adolescent , Adult , Child , Child, Preschool , Dermatitis, Atopic/etiology , Female , Humans , Infant , Male , Middle Aged , Mite Infestations/immunologyABSTRACT
Dermatitis or inflammation of the skin caused by an outside agent, is a condition with many causes. It may result from direct irritation of the skin by a substances (chemical or insecticide) or it may be an allergic reaction to a particular substance that has been in contact with the skin as soap or detergent or insect urticating hairs; injected as insect saliva or faeces or sting or taken by mouth as food or drug. In general, treatment of dermatitis depends mainly upon the cause. In the present study, three species of mites were isolated from the dust collected from houses of atopic dermatitis patients. These mites were Dermatophagoides pteronyssinus, Ornithonyssus bacoti and Haemogamasus pontiger. The former species was the predominant one which is known to produce the most potent allergen. It was concluded that house dust mites are one of the aetiological factors of atopic dermatitis and that genera of mites other than Dermatophagoides may be considered as allergen in house dust mites.
