ABSTRACT
The results of treatment of 697 patients with different kinds of non-specific pleural empyema and gangrenous lesions of lungs are presented in the article. Need for complex and differentiated treatment of pleural empyema with obligatory use of thoracoscopy is revealed. High efficiency of early thoracoscopic sanitation improving outcomes and length of hospital stay is proved. Thoracoscopic necrosectomy is alternative and effective surgery in treatment of gangrenous lesions of lungs.
Subject(s)
Drainage/methods , Empyema, Pleural , Gangrene , Lung Diseases , Pneumonectomy/methods , Thoracic Surgery, Video-Assisted/methods , Algorithms , Early Medical Intervention , Empyema, Pleural/diagnosis , Empyema, Pleural/etiology , Empyema, Pleural/surgery , Female , Gangrene/diagnosis , Gangrene/etiology , Gangrene/surgery , Humans , Length of Stay , Lung Diseases/complications , Lung Diseases/diagnosis , Lung Diseases/therapy , Male , Middle Aged , Moscow , Retrospective Studies , Treatment OutcomeABSTRACT
An analysis of results of examination and treatment of 59 patients with a prolonged duration of acute abscesses of the lungs has shown the influence of immune disorders on the dynamics of the development and outcome of pyo-destructive disease in the lung. The indications to local immunosubstituting therapy were determined. A new original method of administration and a scheme of prescription of the medicine Betaleukin are proposed. Clinical efficiency of the method proposed is shown. The local immunocorrection used in the complex treatment of patients with acute abscesses of the lungs allows to get recovery of 89% of the patients.
Subject(s)
Interleukin-1/administration & dosage , Lung Abscess/drug therapy , Acute Disease , Adult , Aged , Combined Modality Therapy , Follow-Up Studies , Humans , Lung Abscess/diagnosis , Lung Abscess/immunology , Middle Aged , Models, Theoretical , Neutrophils/immunology , Phagocytosis , Recombinant Proteins , Time FactorsABSTRACT
This work reflects the modern concepts of the pathogenesis of insulin-dependent diabetes mellitus and the prospective trends of pharmacological correction, analyzes the possibility of including in the therapeutic complex antiviral drugs, immunocorrecting measures, antioxidants, inhibitors of aldose reductase, amino guanidine, SH-group donors, and new medicamentous forms of insulin. Problems of an individual choice of drugs with consideration for the stage-development of the disease, the main pathogenetic mechanisms, the chronobiological rhythm of drug prescription, and adequate control of the efficacy of the applied pharmacotherapy are discussed.
Subject(s)
Diabetes Mellitus, Type 1/drug therapy , Diabetes Mellitus, Type 1/etiology , Hypoglycemic Agents/therapeutic use , Animals , Autoimmune Diseases/drug therapy , Autoimmune Diseases/etiology , Autoimmune Diseases/metabolism , Circadian Rhythm , Diabetes Mellitus, Experimental/drug therapy , Diabetes Mellitus, Experimental/etiology , Diabetes Mellitus, Type 1/metabolism , Drug Therapy, Combination , Humans , Insulin/therapeutic use , Virus Diseases/complicationsABSTRACT
The paper deals with a description of a procedure of immunoradiometric assay of glutathione S-transferase pi in blood serum. A significantly increased level of said enzyme of more than 9.85 ng/ml in 75% of patients with different cancers of the lung has been established, as compared with non-tumor pathologies. These findings point to the feasibility of application of this enzyme in lung cancer diagnose.
