[The role of functional state of stress-limiting systems in assessing efficacy of early rehabilitation of postmyocardial infarction patients]. / Rol' funktsional'nogo sostoianiia strss-limitiruiushchikh sistem organizma v otsenke éffektivnosti rannego vosstanovitel'nogo lecheniia bol'nykh, perenesshikh infarkt miokarda.

Observation of over 97 postmyocardial infarction convalescents has ascertained that effectiveness of rehabilitation depends much on the function of stress-limiting systems (SLS) of the organism. The best treatment results were achieved in patients with strong SLS. Measurement of SLS indices is recommended in survivors of myocardial infarction on sanatorium treatment.

[Antioxidant effect of low intensity laser infrared irradiation]. / Eksperimental'noe issledovanie antioksidantnogo deistviia nizkointensivnogo lazernogo izlucheniia infrakrasnogo diapazona.

Effects of low-intensive infrared laser (890 nm) exposure on lipid peroxidation (LPO) and antioxidant system (AOS) activity in the membrane fraction of hepatocyte endoplasmatic reticulum (microsomal fraction of the liver) were studied in a physiologically balanced LPO/AOS system (intact animals) and under conditions of LPO initiation by immobilization cold stress (animals with erosions and ulcers of the gastric mucosa after Shay). Antioxidant effect in laser exposure of the liver depends on the frequency of pulses, is mediated by laser effect on hepatocyte membrane structures, and manifests by recovery of LPO/AOS system imbalance induced by disease.

[The effect of low-intensity physical therapeutic factors on the microsomal oxidative systems of the liver in an experiment]. / Vliianie nizkointensivnykh fizicheskikh lechebnykh faktorov na mikrosomal'nye okislitel'nye sistemy pecheni v éksperimente.

The authors' rat experiments have shown that inhibition of pro-oxidant reactions in hepatocyte microsomal fraction in response to hepatic exposure to low-intensive IR-laser radiation and low-intensity ultrasound combines with multidirectional action of these factors on the basic enzymes of the other oxidant system of hepatocyte microsomes--cytochrome P-450-dependent monooxigenase system.

[Change in activity of microsomal cytochrome P-450-dependent monooxygenases from rat liver exposed to chronic low doses of radiation]. / Izmenenie aktivnosti mikrosomal'nykh tsitokhrom-P-450-zavisimykh monoksigenaz pecheni krys pod vliianiem khonicheskogo vozdeistviia malykh doz radiatsii.

The activity changes of cytochrome P-450-dependent monooxygenases of hepatic microsomal fraction were studied in, experimental animals after prolonged application (1 month) of low radiation doses (0.258 mkl/kg). The obtained results show the increase in catalytic activities of main forms of cytochrome P-450, participating in steroid hydroxylation, as well as the decrease in total content of cytochrome P-450 in hepatic microsomal fraction and the lowering of its demethylase activity.

[The effect of local decompression on ovarian function in women operated on for benign epithelial tumors of the ovaries]. / Vliianie lokal'noi dekompressii na funktsional'noe sostoianie iaichnikov zhenshchin, operirovannykh po povodu dobrokachestvennykh épitelial'nykh opukholei iaichnikov.

Mathematical modelling led the authors to the conclusion that local abdominal-vaginal decompression in females operated on for BETO contributes to recovery of functional relations between hormone production by the ovaries, protease-protease inhibitors system, vascular system of the ovaries. It is the impairment of this relationship that is responsible for postoperative complications. Local decompression is recommended as a beneficial physical factor in combined rehabilitation of BETO females.

[Induction of cytochrome P-450 1A1 in rat liver by ultrasound]. / Induktsiia tsitokhorma P-450 1A1 v pecheni krys ultrazvukom.

Rat liver monooxygenase activities, such as androstenedione (AD)-hydroxylase, pentoxyresorufin (PR)- and ethoxyresorufin (ER)-O-deethylases have been studied under contact application of ultrasound (US). In the livers of US-treated rats the AD-hydroxylase activity did not differ from the control, thus suggesting that CYP2A1, CYP2B1, CYP2C11, CYP3A1 were not induced. The rate of ER-deethylation increased from 100 in control up to 300 pmol/min/mg in US-treated rats. Western blot analysis revealed also the CYP1A1 induction in US-treated rats which was absent in untreated animals. The mRNA level for CYP1A1 in the livers of US-treated rats increased from 0.5 up to 6.0 fmol mRNA/total RNA but did not change for CYP1A2. The results obtained provide evidence for the nonchemical induction of CYP4501A1 which is known to be induced by polycyclic aromatic compounds as well as by some other compounds.

[The characteristics of the effect of centimeter-range microwaves on drug pharmacokinetics in the body of experimental animals]. / Osobennosti vliianiia mikrovoln santimetrovogo diapazona na farmakokinetiku medikamentov v organizme éksperimental'nykh zhivotnykh.

The experiments on 130 rat males have shown that the exposure of the animals' liver to centimeter microwaves enhances catalytic activity of P-450p cytochrome, an enzyme of drug microsomal metabolism. However, changes in pharmacokinetic parameters of elimination from the blood of the drugs based on microsomal substrates of hepatic enzymatic system are more dependent on the microwaves' impact on physiological factors modifying drug pharmacokinetics. This implies the necessity of pharmacokinetic investigations in each individual case of combining drugs with microwaves.

[Changes in the drug-metabolizing function of the liver in chronic exposure of the body to low doses of ionizing radiation]. / Izmenenie farmakometaboliziruiushchei funktsii pecheni pri khronicheskom vozdeistvii na organizm malykh doz ioniziruiushchego izlucheniia.

When receiving sanatory treatment in Odessa persons residing at the areas with strict radioecological control (Chernigov, Zhitomir, Kiev Provinces) revealed deterioration of drug metabolism in liver. Experimental data indicated as well suppression of the microsomal drug-metabolizing system of liver caused by long-term exposure of the body to low-dose ionizing radiation. The results obtained should be taken into consideration in such patients for the slowed down drug metabolism in liver may provoke side effects.

[The use of laser radiation for correcting cholesterol metabolic disorders in gallstones]. / Ispol'zovanie lazernogo izlucheniia dlia korrektsii narushenii obmena kholesterina pri zhelchnokamennoi bolezni.

The authors have demonstrated in the experiment that under the influence of irradiation of the liver by means of a semiconductor laser with a wavelength of 890 nm, pronounced activation of its microsomal system occurs. The data obtained have become a basis for the development and introduction in the clinic in 96 patients of a technique of laser correction of hypercholesterolemia. A good therapeutic effect has been noted in all the patients.

[Activity of cytochromes P-450p and P-450h in liver microsomes and blood corticosteroid levels in experimental animals under the action of physical factors]. / Aktivnost' tsitokhromov P-450p i P-450h mikrosom pecheni i uroven' kortikosteroidov v krovi éksperimental'nykh zhivotnykh v usloviiakh vozdeistviia fizicheskimi faktorami.

In experiments on male Wistar rats it has been found that physical factors applied in medicine (laser radiation of low intensity with wave length 0.89 microns, microwaves of centimeter range of 2450 MHz, and ultrasound of low intensity 880 KHz) changed catalytic activity of liver microsomal and rostenedione 16 alpha- and 6 beta-hydroxylating cytochromes P-450h and P-450p and blood corticosteroids level. Activities of these two steroid-metabolizing cytochromes decreased under ultrasonic skin application on liver region and increased under microwave and laser action. Contents of physiologically inactive form of corticosterone were not changed by the physical factors action while level of active hormone was increased under ultrasonic and microwave action. These findings suggest association of the activity of liver steroid-metabolizing cytochromes P-450 and level of physiologically active form of corticosterone in blood under physical factors skin application on liver region.