ABSTRACT
To study the association between disease progression and some clinical features and biochemical spinal fluid parameters, we have examined 209 patients with remitting type of multiple sclerosis. The more rapid progression of multiple sclerosis was associated with male sex, a history of brain concussion, a short first remission, late disease onset, movement disorders at onset of the disease and the high level of platelet endothelial cell adhesion molecule 1 (sPECAM-1) in the spinal fluid.
Subject(s)
Multiple Sclerosis, Relapsing-Remitting/diagnosis , Multiple Sclerosis, Relapsing-Remitting/physiopathology , Adult , Craniocerebral Trauma/complications , Disease Progression , Female , Humans , Male , Middle Aged , Multiple Sclerosis, Relapsing-Remitting/cerebrospinal fluid , Platelet Endothelial Cell Adhesion Molecule-1/cerebrospinal fluid , Sex FactorsABSTRACT
The "case-control" research in Russian Altai territory population has proved that DR15 and DR3 as well as the combination of female sex and alleles A of TNFα of rs1800629 locus are associated with high risk of multiple sclerosis. The relationship between disease and CD40 polymorphism (rs6074022) was not found.
Subject(s)
HLA-DR Antigens/genetics , Multiple Sclerosis/epidemiology , Multiple Sclerosis/genetics , Tumor Necrosis Factor-alpha/genetics , Adult , Alleles , CD40 Antigens/genetics , Female , HLA-DRB1 Chains , Humans , Male , Middle Aged , Polymorphism, Genetic , Risk Factors , Siberia/epidemiologyABSTRACT
Levels of adhesion molecules were measured in 24 patients with multiple sclerosis during the 3-years prospective study. The high level of adhesion molecules sPECAM in the cerebrospinal fluid was associated with the appearance of new foci according to the magnetic resonance imaging data as well as with quick disability.
Subject(s)
Multiple Sclerosis/cerebrospinal fluid , Multiple Sclerosis/diagnosis , Platelet Endothelial Cell Adhesion Molecule-1/cerebrospinal fluid , Vascular Cell Adhesion Molecule-1/cerebrospinal fluid , Adult , Female , Humans , Magnetic Resonance Imaging , Male , Prospective StudiesABSTRACT
Chronic inflammatory diseases of the prostate are accompanied by the accumulation of active oxygen forms and the activation of biopolymer peroxidation. The increased concentration of thiobarbituric acid reactive substances and the decreased activity of antioxidant enzymes in the ejaculate of patients with chronic abacterial prostatitis are attended by spermatozoon defects. It is suggested that correction of the metabolism of active oxygen forms in patients with chronic abacterial prostatitis has a positive effect.
Subject(s)
Antioxidants/metabolism , Prostatitis/metabolism , Prostatitis/pathology , Reactive Oxygen Species/metabolism , Semen/metabolism , Spermatozoa/pathology , Adult , Case-Control Studies , Ejaculation , Humans , Lipid Peroxidation , Male , Middle Aged , Prostatitis/physiopathology , Semen/enzymology , Sperm Motility , Spermatozoa/enzymology , Spermatozoa/metabolism , Young AdultABSTRACT
A total of 28 males aged 20-46 years with chronic abacterial prostatitis (CAP) were divided into two groups. Group 1 patients received standard therapy (prostatotropic, vitamin, antioxidant); group 2 received the same standard treatment plus peloid therapy including silver-containing clay "Bekhtemirskaya". Eleven males with documented fertility (sperm donors) comprised a control group. The participants of the trial were examined for ejaculate indices, activity of the antioxidant system, ion composition of ejaculate, prostatic microcirculation before the treatment, on treatment day 14 and 90. The examination revealed the following disorders in CAP patients: low activity of anti-oxidant enzymes, abnormal static microcirculation, low content of normal spermatozoa in ejaculate. Complex rehabilitation of the patients of both groups improved prostatic microcirculation, raised activity of the antioxidant system resulting in better mobility and viability of spermatozoa. In group 2 the results were better showing the efficacy of local peloid therapy.
