ABSTRACT
Erectile dysfunction (ED) negatively impacts self-esteem and relationship satisfaction. The Self-Esteem and Relationship (SEAR) questionnaire is a validated, ED-specific, patient-reported instrument that specifically addresses self-esteem and relationship issues within the context of ED. Effective ED treatment with sildenafil in a double-blind, placebo-controlled clinical trial conducted in Brazil, Mexico, Australia and Japan showed pooled cross-cultural improvements in self-esteem, confidence and relationship satisfaction. This report focuses on the results from the subgroup of men from nine Mexican centers who participated in the multinational study. A total of 95 men aged >or=18 years with clinically diagnosed ED and currently in a stable relationship were randomized to placebo (n=47) or sildenafil (n=48). The SEAR results for Mexican men showed that sildenafil treatment led to significant improvements in self-esteem, confidence and relationship satisfaction. These data support an earlier study showing that Latin American men taking sildenafil have similar safety and efficacy profiles compared to non-Latin counterparts.
Subject(s)
Erectile Dysfunction/drug therapy , Erectile Dysfunction/psychology , Patient Satisfaction , Piperazines/therapeutic use , Self Concept , Sulfones/therapeutic use , Double-Blind Method , Humans , Male , Mexico , Middle Aged , Piperazines/adverse effects , Purines/adverse effects , Purines/therapeutic use , Sildenafil Citrate , Sulfones/adverse effects , Surveys and QuestionnairesSubject(s)
Carcinoma, Renal Cell/pathology , Kidney Neoplasms/pathology , Magnetic Resonance Imaging , Military Personnel , Aged , Carcinoma, Renal Cell/diagnostic imaging , Carcinoma, Renal Cell/epidemiology , Female , Hospitals, Military/statistics & numerical data , Humans , Kidney/diagnostic imaging , Kidney/pathology , Kidney Neoplasms/diagnostic imaging , Kidney Neoplasms/epidemiology , Magnetic Resonance Imaging/statistics & numerical data , Male , Mexico/epidemiology , Middle Aged , Military Personnel/statistics & numerical data , Neoplasm Staging , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
Veinte pacientes de ambos sexos con infeccion del tracto urinario, fueron tratados con una combinacion de rifampicina 300 mg y trimetoprim 80 mg, 2 tabletas por la noche, 2 horas antes o despues de los alimentos, durante 10 dias. En 17 de estos pacientes la respuesta clinica y bacteriologica fue satisfactoria.Los tres restantes tenian complicaciones que a juicio nuestro podrian determinar la persistencia de la infeccion, pero tuvieron respuesta clinica satisfactoria. La tolerancia fue buena en todos y no hubo evidencia de efectos secundarios
Subject(s)
Rifampin , Trimethoprim , Urinary Tract Infections , Drug CombinationsABSTRACT
A 30 year old patient with normal masculine phenotype, karyotype 46 XY with a congenital left inguinal hernia, was studied. This hernia contained (at surgery): uterus, tubes and a hypoplasic vagina, as well as testis. The Müllerian structures and the right testicle, were resected, and left orchidopexy was performed. FSH, LH, testosterone, prolactine, B-HCG in blood by radioimmunoanalysis, total estrogens, 17-ketosteroids and 17-hydroxicorticosteroids in urine, were all normal. Roentgenologic and endoscopic urologic studies were normal. A post-operative study of semen showed moderate oligospermia. The factors involved in masculine sexual differentiation, were reviewed, specially the inhibitory factor of Müllerian structures.
