[Toxicity of binary "theraphthal-Lio+ascorbic acid" (TPH+AA) catalytic system during different methods of regional intra-arterial administration in dogs]. / Toksichnost' binarnoi kataliticheskoi sistemy "teraftal-Lio+askorbinovaia kislota" ("TF+AK") pri razlichnykh metodakh regionarnogo vnutriarterial'nogo vvedeniia sobakam.

A binary teraphtal-Lio + ascorbic acid (Tph + AA) catalytic system has been tested for untoward side-effects using three procedures of regional intraarterial infusion on dogs. On the basis of the data on local-tissue and overall toxicity, an optimal one was selected and recommended for clinical use.

[Antiviral activity of the natural immunostimulant "Vegetan" in murine herpetic meningoencephalitis, guinea pig genital herpes, and canine parvoviral enteritis]. / Antivirusnaia aktivnost' prirodnogo immunostimuliatora "Vegetan" pri gerpeticheskom meningoéntsefalite myshei, genital'nom gerpes morskikh svinok i parvovirusnom énterite sobak.

Antiviral activity of vegetan, a new natural immunostimulator, in herpetic meningoencephalitis of mice, genital herpes of guinea pigs, and parvoviral enteritis of dogs was compared to that of acylguanosine and phosphonoformic acid (PFA). Vegetan incorporated in liposomes or pure was the most active if used for prevention 5 days before intracerebral infection of mice with herpes simplex type 1 virus, whatever the dose of infective agent (10 to 100 LD50). Protective efficacy of vegetan was 57-63%, whereas for ara-A, acylguanosine, and PFA these values were, respectively, 20, 25, and 33%. Use of liposomal vegetan preparation ensured a 80% protective effect. Vegetan had a manifest antiviral effect in guinea pigs with genital herpes and in dogs with parvoviral enteritis.

[Steroid hormone receptors in malignant mammary gland tumors in dogs]. / Retseptory steroidnykh gormonov v zlokachestvennykh opukholiakh molochnykh zhelez sobak.

The content of estrogen (ER) and progesteron receptors (PR) were studied as related to histological type, the degree of malignancy and growth rate of spontaneous canine mammary carcinomas. No correlation was found between the ER and PR amount, histological type and degree of malignancy. Inverse correlation was detected between ER and PR and the growth rate. These results correspond to those obtained for human mammary tumours. Therefore canine mammary carcinomas can be considered as an adequate model for experimental therapy of this type of tumours.

[Antineoplastic and toxic effects of blastolysin in the treatment of spontaneous mammary cancer in dogs]. / Protivoopukholevoe i toksicheskoe deistvie blastolizina pri terapii spontannogo raka molochnykh zhelez u sobak.

The anticancer activity and toxicity of blastolysin were studied in 13 dogs with mammary cancer using two different schedules. The agent was given 5 times in a dose of 2.5-10 mg/kg with a 72 h interval (the first schedule) and 10 times in a dose of 0.4-1.7 mg/kg in 24 h (the second schedule). The first schedule exhibited the highest anticancer effect with the least toxicity. Blastolysin was found to depress erythropoiesis.