1.
J Am Chem Soc
; 131(41): 14608-9, 2009 Oct 21.
Article
in English
| MEDLINE
| ID: mdl-19824719
ABSTRACT
The enantioselective alkynylation of benzylidene Meldrum's acids has been successfully achieved through rhodium-catalyzed addition of TMS-acetylene in the presence of bisphosphine ligand 3,5-Xylyl-MeOBIPHEP. The resulting Meldrum's acids were obtained in good yields and up to 99% enantiomeric excess. The alkynylation method is carried out under mild reactions conditions and is compatible with an array of functional groups.