ABSTRACT
Experimental data have been presented which prove antibacterial efficiency of interferon preparations and inducers under infection processes evoked by Staphylococcus aureus, Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae. It is shown that the system of phagocytizing cells and natural cells-killers plays the basic protective role in the organism under the persistence of these microbes. The basic regularities of activating effect of interferon preparations and its inducers on the functional activity of the above mentioned cells have been found. The methods of treatment with interferon drugs based on experimental data have been developed for the first time. They were used to cure patients with pyo-septic diseases.
Subject(s)
Anti-Infective Agents/therapeutic use , Interferon Inducers/therapeutic use , Interferons/therapeutic use , Animals , Bacterial Infections/drug therapy , Clinical Trials as Topic , Drug Evaluation, Preclinical , Humans , Recombinant Proteins/therapeutic useABSTRACT
Cytokines (interferons, tumour necrosis factor and interleukin-1) with marked polyfunctional properties are described. They are synthesized by different cells of both immune and non-immune systems of organism and are able to stimulate, induce or inhibit various immunological and biological reactions and processes. The effect exerted by these cytokines on the course of bacterial infections is analyzed. The cytokines possess protective properties which are demonstrated in activation of neutrophils, intensification of bactericidal and phagocytic activity of macrophages and natural cells-killers.