ABSTRACT
Aims: To compare fine-needle aspiration cytology (FNAC) with imprinted gene detection in the differential diagnosis of benign and malignant thyroid nodules. Methods: A total of 34 patients (35 cases of thyroid nodules) were examined using fine-needle puncture biopsy under ultrasound guidance, and the biopsy tissues were examined by cytologic examination and imprinted gene detection. Combined with postoperative pathology and follow-up results, the diagnostic value and consistency of the two methods were analyzed and compared. Results: The detection of benign and malignant thyroid nodules by ARHI imprinted gene had a high consistency with FNAC, and ARHI imprinted gene detection had a higher detection rate, sensitivity, and accuracy. Conclusions: Imprinted gene detection has high accuracy and sensitivity in the differential diagnosis of benign and malignant thyroid nodules. It provides a scientific reference for clinical treatment and should be incorporated into diagnostic protocols for thyroid tumor.
Subject(s)
Thyroid Neoplasms/diagnosis , Thyroid Nodule/diagnosis , rho GTP-Binding Proteins/genetics , Adenocarcinoma, Follicular/diagnosis , Adenocarcinoma, Follicular/pathology , Adolescent , Adult , Aged , Biopsy, Fine-Needle , Carcinoma, Papillary, Follicular/diagnosis , Carcinoma, Papillary, Follicular/pathology , Diagnosis, Differential , Epithelial Cells/cytology , Female , Genomic Imprinting , Goiter, Nodular/diagnosis , Goiter, Nodular/pathology , Hashimoto Disease/diagnosis , Hashimoto Disease/pathology , Humans , Male , Middle Aged , Thyroid Gland/pathology , Thyroid Neoplasms/pathology , Thyroid Nodule/diagnostic imaging , Thyroid Nodule/pathology , Thyroiditis, Subacute/diagnosis , Thyroiditis, Subacute/pathology , Ultrasonography , Young AdultABSTRACT
Hashimoto's thyroiditis is a type of autoimmune thyroid disease with an increasing prevalence in past decades. Its diagnosisis mostly based on ultrasonography. Ultrasonography is a useful and essential tool to make this diagnosis based on the characteristics of the disease. In the differential diagnosis of thyroid nodules, ultrasound-guided fine-needle biopsy is an effective method to distinguish Hashimoto's thyroiditis from other thyroid disorders. One exciting and recent advance is that non-invasive ultrasound-based methods have supplemented fine-needle aspiration to diagnose Hashimoto's thyroiditis under more complex conditions. In this review, we discuss the recent advantages of ultrasonography in the diagnosis of Hashimoto's thyroiditis.
Subject(s)
Hashimoto Disease/diagnostic imaging , Diagnosis, Differential , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Hashimoto Disease/complications , Hashimoto Disease/diagnosis , Humans , Thyroid Diseases/complications , Thyroid Diseases/diagnostic imaging , Thyroid Nodule/complications , Thyroid Nodule/diagnostic imaging , UltrasonographyABSTRACT
OBJECTIVE: To investigate the feasibility of determination of right ventricular outflow tract (RVOT) high septal pacing site visualized by real-time three-dimensional echocardiography (RT3DE). METHODS: The forty subjects with RVOT pacing were analysed. RT3DE determination of RVOT high septal pacing sites was compared with chest X-ray (CXR). RESULTS: RVOT septal pacing sites could be obtained in all patients by RT3DE.When pacing sites were categorized as septal or non-septal, there were good agreements between echocardiography and CXR (kappa = 0.745). However, when RVOT pacing sites were categorized as high septal or non-high septal in identifying the exact anatomic location of pacing sites, there was only mild agreement between echocardiography and CXR (kappa = 0.275). Moreover, when RT3DE was used as the gold standard in identifying the exact anatomic location of RVOT, pacing at the RVOT high septal could only be achieved in 37.5% (n= 15) of patients using RT3DE, but in 65% (n= 26) using CXR, because the RVOT septal pacing lead tip found at high septal by CXR is actually found at low septal or free wall by RT3DE. CONCLUSION: It is limited to accurately locate RVOT high septal pacing site only by CXR, RT3DE allows to determinate the RVOT high septal pacing sites helpfully.
