LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5.

Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5, by L.-Y. Guo, C.-F. Qin, H.-X. Zou, M.-Y. Song, M.-L. Gong, C. Chen, published in Eur Rev Med Pharmacol Sci 2019; 23 (6): 2374-2379-DOI: 10.26355/eurrev_201903_17382-PMID: 30964162" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17382.

Utility of the lateral arm free flap in oral cavity reconstruction: a single-centre experience with Chinese patients.

The lateral arm flap (LAF) may offer an alternative option for oral cavity repair. Twenty-five Chinese patients with oral cavity defects were reconstructed with a LAF. The anatomical characteristics of the flap, the donor site complications, and the functional and aesthetic assessments of recipient site were reviewed. The overall flap survival was 96.0% (24/25patients). The average pedicle length was 7.07±1.09cm when it was cut off at the insert of the deltoid, with an average arterial diameter of 1.30±0.37mm and vein diameter of 2.06±0.48mm. The average flap length was 7.06±1.01cm, and the average flap breadth was 5.28±0.66cm, with the average flap size ranging from 18 to 42cm2. One to three reliable perforators supplied the flap, with the proximal, middle, and distal perforators being located at 9.9±1.1cm, 8.6±1.4cm, and 5.7±1.2cm from the lateral epicondyle, respectively. The donor defect was closed primarily and healed uneventfully. A longitudinal scar was the most common morbidity of the donor site. The function and shape of the reconstructed tissues were well restored. The LAF provides a reliable choice for reconstructing medium-sized oral cavity defects, with minimal donor-site morbidity and ideally functional and aesthetic rehabilitation of the recipient site.

LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5.

OBJECTIVE: Recent studies have determined the crucial role of long noncoding RNAs (lncRNAs) in cancer development. Cervical cancer (CC) is a common type of fatal gynecological cancer worldwide. This study aims to identify the role of lncRNA AB073614 in the progression of CC. PATIENTS AND METHODS: Relative level of AB073614 in 3 CC cell lines and 48 paired CC samples was determined by the quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The potential regulatory effects of AB073614 on the cellular behaviors of CC cells were explored through apoptosis assay, colony formation assay, and proliferation assay in vitro. The underlying mechanism of AB073614 in mediating the progression of CC was also conducted. RESULTS: The AB073614 expression was remarkably higher in CC tissues than that in adjacent tissues. The knockdown of AB073614 inhibited proliferation but induced apoptosis of CC cells. In addition, RBM5 (RNA binding motif 5) was upregulated in CC cells after knockdown of AB073614 in vitro. Furthermore, a negative correlation was seen between the expressions of RBM5 and AB073614 in CC tissues. CONCLUSIONS: AB073614 could promote proliferation and inhibit apoptosis of CC cells through downregulating RBM5, which may offer a new therapeutic intervention for CC patients.

Clinical effects of ascending colon patching ileorectal heart-shaped anastomosis on total colonic aganglionosis.

OBJECTIVE: We studied the clinical effects of ascending colon patching ileorectal heart-shaped anastomosis in treating total colonic aganglionosis. PATIENTS AND METHODS: From June 2006 to June 2013, 15 children with severe abdominal distension, low small intestine obstruction and intestinal perforation in the neonatal period, were enrolled in this study. In phase I, patients received emergency terminal ileum stoma plus multi-site colonic biopsy and 6 to 12 months later, ascending colon patching ileorectal heart-shaped anastomosis was conducted in phase II. The occurrence of postoperative complications was recorded. Patients' defecation and anal manometry during the follow-up period were monitored and recorded. All operations were successful, and the average hospitalization time was 10.5 days, and the average amount of bleeding was 30 mL. RESULTS: There were 2 cases of enterocolitis, but no intestinal anastomotic leakage, no incision infection, no anal stenosis and no mortality. Postoperative follow-up lasted for 1 to 2 years with an average of 1.2 years. Perianal redness and erosion occurred in an early stage after the operation, but disappeared after 6 months. Postoperative defecation frequency was about 6 to 9 times, but after 2 years this frequency reduced to 2 to 3 times. Feces transformed from watery into soft forms. Normal results were obtained in the detection of serum K+, Na+, Cl-, HCO3-, hemoglobin, albumin and globulin levels in postoperative follow-up. Rectal rest pressure and anal canal rest pressure after a radical operation on megacolon were significantly lower than those of before operation (p < 0.05). CONCLUSIONS: Ascending colon patching ileorectal heart-shaped anastomosis preserved right hemicolon with relatively good absorptive capability and complied with the physiology of colon. Meanwhile, the ileorectal heart-shaped anastomosis was conducted. The anastomotic stoma was in an oblique heart shape, and its aperture was wide and in different planes without stenosis, blind bag and gate syndrome. We concluded that ascending colon patching ileorectal heart-shaped anastomosis was an effective and feasible method for the radical operation on total colonic aganglionosis.

Laparoscopic surgery treatment of children with appendiceal abscess.

OBJECTIVE: To evaluate the feasibility of treatment for children with appendiceal abscess by laparoscopic surgery and investigate its superiorities to conventional treatments. PATIENTS AND METHODS: 45 children with appendiceal abscess who were treated with laparoscopic surgery from January 2011 to July 2011 were reviewed and analyzed. The age of children ranged from 7 months to 5 years. 37 children received emergency operations, among which 8 children additionally received laparoscopic surgery. 40 children received laparotomy for treatment of appendiceal abscess, and 28 children whose condition was ameliorated after the conservative anti-inflammatory treatment received laparoscopic surgery. RESULTS: Operations of 45 children were successful, and lasted for 35 to 130 minutes with an average time of 75 minutes. There was no obvious difference in comparison of duration of laparotomy between the two groups (p > 0.05). But the laparoscopy resulted in fewer complications than the laparotomy with a statistical significance difference (p < 0.05). Moreover, the operation time for laparoscopy was shorter than that of laparotomy, but the difference in incidence rates of complications after the operation had no statistical significance (p > 0.05). The overall length of stay was apparently prolonged in two groups with a statistically significant difference (p < 0.05). CONCLUSIONS: If the operation and perioperative period are handled properly, treating children with appendiceal abscess by laparoscopic surgery is safe and feasible.

The potential role of attitudes towards suicide between mental health status and suicidal ideation among Chinese children and adolescents.

BACKGROUND: The objective of this study was to investigate the contributions of mental health status and attitudes towards suicide on suicidal ideation in a sample of 6568 Chinese children and adolescents in China. Attitudes towards suicide were investigated as a possible moderator and mediator of the influence of mental health status on suicidal ideation. METHODS: Descriptive statistical analyses, Pearson correlation analyses and hierarchical regression analyses were adopted as methods of data analyses. RESULTS: Approximately 35.38% of children and adolescents in our study reported having suicidal ideation. Mental health status and attitudes towards suicide both had an independent effect on the severity of suicidal ideation. Results indicated that mental health status was positively associated with suicidal ideation, while attitudes towards suicide were negatively associated with suicidal ideation. Moderation analysis showed that the impact of mental health status on suicidal ideation was significantly greater among children and adolescents who reported favourable attitudes towards suicide. Attitudes towards suicide partially mediated the link between mental health status and the severity of suicidal ideation. Specifically, students who experienced poorer mental health status might be more likely to report significantly more favourable attitudes towards suicide, which in turn promote greater suicidal ideation. CONCLUSIONS: These results have implications for the prevention of youth suicide, suggesting that mental health status and attitudes towards suicide could be important targets for prevention and intervention for children and adolescents at risk of suicidal ideation.