New treatment strategy of cryosurgery and temperature control.

Cryosurgery, recommended as an effective method for tumor treatment, has been widely used in clinics. However, it might lead to a high probability of tumor recurrence due to incomplete tumor damage. The treatment protocol for cryosurgery is essential to achieve the desired therapeutic effects. In this study, a new temperature fluctuation treatment method was proposed, and the fuzzy control method based on piecewise adjustment was developed for temperature control during the treatment. Ex vivo rat liver experiments were conducted and histopathology analysis used to study the therapeutic effects of the new treatment method.