1.
AIDS
; 24(10): 1593-5, 2010 Jun 19.
Article
in English
| MEDLINE
| ID: mdl-20539093
ABSTRACT
We examined factors associated with virological failure in 310 HIV-infected patients receiving atazanavir (ATV). Independent links were identified with virological failure under ATV: virological failure previous history (P = 0.006) and ATV underdosing (P = 0.04). A maintenance therapy was protective (P = 0.01). The optimal therapeutic ranges of ATV concentration were found to be from 300 ng/ml (or 180 for patients treated with maintenance therapy) to 650 ng/ml for C24 and from 1000 ng/ml (or 500 for patients treated with maintenance therapy) to 2000 ng/ml for C12.
Subject(s)
Anti-HIV Agents/administration & dosage , HIV Infections/drug therapy , HIV-1/drug effects , Oligopeptides/administration & dosage , Pyridines/administration & dosage , Adult , Aged , Atazanavir Sulfate , Drug Administration Schedule , Female , HIV Infections/virology , Humans , Male , Middle Aged , ROC Curve , Viral Load , Young Adult
2.
AIDS
; 20(7): 1087-9, 2006 Apr 24.
Article
in English
| MEDLINE
| ID: mdl-16603872
