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3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages.
Dokovic, Dejan D; Bulatovic, Vanja M; Bozic, Biljana D; Kataranovski, Milena V; Zrakic, Tomislav M; Kovacevic, Nada N.
Chem Pharm Bull (Tokyo) ; 52(7): 853-4, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15256707

ABSTRACT

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC(50)=6.7+/-0.8 microM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.


Subject(s)
Alkynes/chemistry , Alkynes/pharmacology , Apiaceae , Macrophages, Peritoneal/drug effects , Nitric Oxide/antagonists & inhibitors , Oils, Volatile/pharmacology , Rhizome , Alkynes/isolation & purification , Animals , Macrophages, Peritoneal/metabolism , Male , Nitric Oxide/metabolism , Oils, Volatile/isolation & purification , Plant Roots , Rats
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