ABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Nerve Block/instrumentation , Nerve Block/methods , Nerve Block , Polyneuropathies/complications , Polyneuropathies/drug therapy , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/complications , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/drug therapy , Nerve Block/standards , Nerve Block/trends , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathologyABSTRACT
La colitis ulcerosa es una enfermedad intestinal que cursa con brotes intermitentes. En la actualidad la exacerbación de la enfermedad se ha asociado con la sobreinfección por citomegalovirus, que empeora el cuadro. Presentamos un caso de una paciente con colitis ulcerosa que durante la gestación desarrolla un brote grave que llega a producir un megacolon tóxico. Posteriormente se comprueba que durante este brote tuvo una sobreinfección por citomegalovirus, produciéndose la transmisión maternofetal del virus, por lo que el feto presenta lesiones características de esta infección
Ulcerative colitis is an inflammatory bowel disease characterized by intermittent flares of disease activity. Exacerbations have been associated with cytomegalovirus superinfection. We report the case of a pregnant woman who experienced a severe flare, producing toxic megacolon. Cytomegalovirus infection during this flare was subsequently confirmed. Maternofetal transmission of the virus occurred and the fetus showed the lesions characteristic of this infection
Subject(s)
Female , Pregnancy , Adult , Humans , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/virology , Cytomegalovirus , Cytomegalovirus Infections/complications , Cytomegalovirus Infections/diagnosis , Colitis, Ulcerative/diagnosis , Colitis, Ulcerative/virology , Abortion, Legal , Cytomegalovirus Infections/transmission , Infectious Disease Transmission, VerticalABSTRACT
Objetivos: Conocer la incidencia de la trisomía 21 en nuestra población y la tasa de detección prenatal con el actual método de cribado poblacional. Material y método: Estudio observacional, longitudinal, retrospectivo, entre el 1 de enero de 1995 y el 31 de diciembre de 2002. Resultados: La incidencia global de la trisomía 21 en nuestro medio es de 2,09 cada 1.000 recién nacidos. Uno de cada 3 casos de trisomía 21 se diagnostica en mujeres no añosas. La tasa de detección de la edad materna en nuestro medio es del 45,66 por ciento. El 58,18 por ciento de los diagnósticos posnatales de síndrome de Down se realizaron en gestantes menores de 35 años, en quienes sólo se diagnosticó prenatalmente el 13,51 por ciento de las trisomías 21. Conclusiones: El cribado poblacional de la trisomía 21 en nuestro medio es insuficiente. Proponemos un cribado secuencial, que combina la edad materna y la translucencia nucal con cribado bioquímico entre las semanas 11 y 14 (AU)
Subject(s)
Adult , Female , Humans , Mass Screening , Down Syndrome/epidemiology , XYY Karyotype/diagnosis , XYY Karyotype/epidemiology , Abortion/complications , Abortion/diagnosis , Amniotic Fluid/cytology , Amniocentesis/methods , Amniocentesis , Spain/epidemiology , Signs and Symptoms , Longitudinal Studies , Retrospective StudiesABSTRACT
La adenomatosis quística pulmonar es una rara malformación congénita que consiste en un hamartoma torácico con un excesivo crecimiento de diversas capas de bronquío los y alvéolos que característicamente puede comprender desde quistes: a masas prácticamente sólidas localizadas en el pulmón y cuyo diagnóstico prenatal es posible mediante técnicas ultrasonográficas (AU)
Subject(s)
Adult , Pregnancy , Female , Humans , Cystic Adenomatoid Malformation of Lung, Congenital , Ultrasonography, Prenatal , alpha-Fetoproteins/analysis , Abortion, Therapeutic , Polyhydramnios/complications , Hydrops Fetalis/complicationsABSTRACT
La malformación adenomatoide congénita quística del pulmón es una rara anomalía que debe sospecharse siempre ante alteraciones pulmonares o hidropesía en el estudio ecográfico prenatal, para lograr un diagnóstico temprano e intentar un tratamiento en los casos en que sea posible. (AU)
Subject(s)
Adult , Pregnancy , Female , Humans , Cystic Adenomatoid Malformation of Lung, Congenital , Ultrasonography, Prenatal/methods , alpha-Fetoproteins/analysis , Abortion, Therapeutic , Fetal DiseasesABSTRACT
A statistically exhaustive, 8800 compound tripeptidal amidomethylcoumarin library was synthesized as discreet compounds using solid-phase combinatorial chemistry. A subset of the compounds was purified by HPLC and tested in a high-throughput fluorometric assay against several known serine and cysteine proteases to demonstrate the utility of this library for profiling protease substrate specificity.
Subject(s)
Coumarins/chemical synthesis , Endopeptidases/metabolism , Fluorescent Dyes/chemical synthesis , Chromatography, High Pressure Liquid , Combinatorial Chemistry Techniques , Coumarins/chemistry , Fluorescent Dyes/chemistry , Molecular Probes , Substrate SpecificitySubject(s)
Dementia/nursing , Aged , Clinical Protocols , Humans , Nursing Diagnosis , Primary NursingABSTRACT
Allergenic cross-reactivity among six basidiomycete species (Calvatia cyathiformis, Coprinus quadrifidus, Psilocybe cubensis, Pleurotus ostreatus, Ganoderma meredithae, and Pisolithus tinctorius) was determined by immunoprint inhibition. Extensive cross-reactivity was demonstrated among Coprinus quadrifidus, Psilocybe cubensis, and Pleurotus ostreatus of the order Agaricales, and Calvatia cyathiformis of the order Lycoperdales. However, G. meredithae (order Aphyllophorales) and Pisolithus tinctorius (order Sclerodermatales) did not demonstrate significant cross-reactivity with the other basidiomycete species. Generally, the two most potent inhibitors were Psilocybe cubensis and Pleurotus ostreatus. Inhibitory dose-response curves of a major allergenic band (isoelectric point, 9.3) were obtained by densitometry. Significant cross-reactivity was demonstrated for the 9.3 band among the species of the order Agaricales and with Calvatia cyathiformis. The most potent inhibitors were again Psilocybe cubensis and Pleurotus ostreatus. Thus, there is substantial allergenic cross-reactivity among the species of the order Agaricales tested and with Calvatia cyathiformis but not between these four species and G. meredithae or Pisolithus tinctorius. These studies support earlier RAST-inhibition observations of shared allergenic epitopes among basidiomycetes, especially epitopes within the Agaricales. The presence of shared epitopes suggests the possibility of devising a panel of skin test reagents representative of a large group of basidiomycetes.